TORONTO (AP) - Miguel Cabrera homered twice, Brandon Inge connected for the third consecutive game and the Detroit Tigers beat the Toronto Blue Jays 5-1 on Wednesday night for their first victory of the season.

Zach Miner allowed one run and six hits in 5 2-3 innings for Detroit, which lost its first seven games last year and finished last in the AL Central.

The Tigers were beaten 12-5 on opening day this season and absorbed a difficult 5-4 loss Tuesday in a game they led 3-0 through seven innings.

Cabrera made sure the opening-week slump would not continue, hitting a three-run drive in the first and a solo shot in the fifth that bounced off the center-field restaurant at Rogers Centre.

Cabrera added a single in the eighth and finished 3-for-4. He is 7-for-10 with two walks this season.

Inge added a solo shot in the sixth for the Tigers, who have six homers in three games.

Bobby Seay followed Miner (1-0) with 1 1-3 innings, Ryan Perry tossed a perfect eighth in his major league debut and Fernando Rodney finished for Detroit. Curtis Granderson crashed into the wall in center to snare Lyle Overbay 's drive for the final out.

The Tigers jumped on Jesse Litsch in the first. Placido Polanco and Magglio Ordonez singled to bring up Cabrera, who drilled the first pitch over the wall in left for his first homer of the season.

The Blue Jays got one back in the bottom half when Marco Scutaro and Aaron Hill hit back-to-back doubles. Alex Rios followed with a single and Vernon Wells walked to load the bases for Adam Lind , but Toronto couldn't sustain the rally. Hill was forced out at the plate on Lind's grounder and Rios was thrown out at home by Josh Anderson on Scott Rolen 's fly to shallow right.

Litsch (0-1) surrendered five runs and seven hits in six innings for Toronto.

Notes: Thursday's series finale will mark the first time since baseball's draft began in 1965 that two first-round picks will face each other in their respective major league debuts. Toronto will start left-hander Ricky Romero , the sixth-overall pick in 2005, while Detroit counters with right-hander Rick Porcello , taken 27th in 2007. ... Wednesday's loss denied the Blue Jays the third 3-0 start in club history. Toronto started 3-0 in 1992 and 1996.