BALTIMORE(AP) Vladimir Guerrero hit two homers and had five RBIs, Kendry Morales and Maicer Izturis also homered, and the Los Angeles Angels pulled away to an 8-5 win over the Baltimore Orioles on Monday night.

The score was tied at 2 before the Angels scored three runs in the sixth inning and three in the seventh.

Izturis broke the tie with a solo shot off rookie David Hernandez (4-5) in the sixth. Bobby Abreu followed with a single before Guerrero hit a drive over the center-field wall.

In the seventh, Cla Meredith walked Chone Figgins and issued a two-out intentional walk to Abreu before Guerrero homered to center. The Angels' cleanup hitter has 10 home runs this season, 402 for his career and 38 career multihomer games.

Ervin Santana (6-6) allowed three runs and seven hits in six innings to win his third straight start.

Brian Fuentes got the final out for his 34th save.

Los Angeles took three of four from Baltimore to improve to 22-8 since the All-Star break. The Angels have won six of seven overall and 20 of their last 26 on the road.

Nick Markakis hit a solo homer in the sixth inning and Melvin Mora delivered a two-run drive in the ninth for the last-place Orioles, who fell 22 games under .500 (48-70).

After trading first baseman Aubrey Huff to Detroit for a minor leaguer earlier in the day, Baltimore was left with 24 players. Luke Scott received his initial major league start at first base and Markakis filled Huff's usual role as the cleanup hitter.

Scott played the position flawlessly in the start of a seven-week experiment to see if he has the defensive prowess to begin the 2010 season as Baltimore's everyday first baseman. Markakis, meanwhile, extended to 37 his career-best run of games reaching base.

Two singles and a run-scoring grounder by Adam Jones put Baltimore up 1-0 in the first before Santana struck out Matt Wieters with two outs and runners at second and third.

Morales gave Los Angeles a 2-1 lead with his 25th home run, a drive to right after Juan Rivera hit a one-out single.

Baltimore tied it in the third on a two-out RBI double by Markakis.

Notes: Angels CF Torii Hunter was rested after playing 13 innings Sunday in his return from the DL. ... Los Angeles won the season series 7-2. ... LA is 28-4 in Guerrero's last 32 games with a homer.