BOSTON (AP) -- John Lackey settled down after a shaky start with big assists from his slick-fielding second baseman and his hard-hitting teammates.
With the bases loaded and no outs in the third, Dustin Pedroia stabbed a sharp grounder by Casey McGehee to start a double play on which a run scored, tying the game at 4, but took the steam out of a second-inning rally.
"That's going to be a couple of runs, maybe second and third," Boston manager Terry Francona said after the Red Sox beat the Milwaukee Brewers 10-4 on Friday night. "That was the biggest play of the game."
Lackey then retired the next 14 batters, with only two getting the ball out of the infield, and the Red Sox won for the 12th time in 13 games.
"Any time it goes Pedey's way, you have a chance," Lackey said. "He's the best."
So are the Red Sox hitters. They lead the majors with a .274 batting average after pounding 14 hits, three each by Adrian Gonzalez and David Ortiz .
"That's one thing you can hang your hat on when you're out there," said Lackey (5-5), who is 3-0 since coming off the disabled list. "If you give up a couple of runs, hang in there because the boys are coming. They can really swing."
The hitters got a break when the Brewers were forced to go to their bullpen early after Shaun Marcum left following the first inning with a strained left hip flexor. He had given up two runs on four hits and was replaced by Marco Estrada (1-4), who allowed a go-ahead homer to Gonzalez that gave Boston a 5-4 lead in the fifth.
Marcum thinks he'll be able to make his next scheduled start.
"I didn't want to come out after the inning, but we wanted to be smart about it," he said. "I'll come in (Saturday) and see where we're at. Hopefully, the tightness will be out of there for the most part."
The Red Sox lost two players for the second straight day.
Left fielder Carl Crawford departed after suffering a Grade 1 hamstring strain in the first, the least serious kind, according to Francona. He was hurt while beating out an infield single, and Francona said more evaluation needed to be done to determine the next step. Third baseman Kevin Youkilis , who was feeling ill, was replaced by Drew Sutton in the top of the fifth.
In Thursday night's 4-2 win at Tampa Bay starter Clay Buchholz left early with back problems and shortstop Jed Lowrie came out with a shoulder injury.
Boston increased its AL East lead to 2 1/2 games over the New York Yankees , who lost 3-1 to the Chicago Cubs . Milwaukee's lead in the NL Central remained at one game over the St. Louis Cardinals, who lost to the Kansas City Royals 5-4.
Lackey gave up four runs before getting an out in the third. Then Pedroia started the double play after four consecutive singles by Rickie Weeks , Nyjer Morgan , Ryan Braun and Prince Fielder .
"Huge play," Milwaukee manager Ron Roenicke said. "We've got a chance to have a big inning there and it's not the first time I've seen him do it. The guy can play."
The Red Sox's potent offense resurfaced after they scored just seven runs in a three-game series at Tampa Bay, although they won two of them. During their nine-game winning streak going into that series, they averaged 9.2 runs.
Milwaukee's fourth loss in five games ended with a perfect ninth by Matt Albers , who struck out two batters.
The Brewers scored two runs in the first on a single by Morgan, a double by Fielder and a two-run single by McGehee.
Lackey "was throwing the ball well" from the start, Red Sox catcher Jason Varitek said. "He made one mistake in the first inning and McGehee did a nice job of hitting."
Roenicke was bench coach for the Los Angeles Angels the past five seasons - the first four of them with Lackey on the team.
"We saw (Lackey struggle) at the beginning and then the last few innings is the guy I know," Roenicke said.
The Red Sox tied it in the bottom of the first on a leadoff homer by Jacoby Ellsbury , a single by Gonzalez and an RBI double by Ortiz.
Boston went ahead 4-2 in the second on a walk to Pedroia, a double by Gonzalez and a two-run single by Youkilis. After Gonzalez's homer, they added two runs in the sixth and three in the seventh.
Notes: Ellsbury's homer was his second of the season and fifth of his career when leading off the first inning for Boston. ... The first inning lasted 43 minutes. Marcum threw 44 pitches and Lackey 25. ... Braun extended his hitting streak to 10 games with his single in the third. ... The Brewers lost for the 11th time in their last 12 games at Fenway Park. ... Red Sox closer Jonathan Papelbon had his suspension for making contact with an umpire reduced by major league baseball from three games to two. He was ejected after the incident with plate umpire Tony Randazzo on June 4 at Fenway against Oakland. ... Francona held his pregame press conference while wearing a Bruins jersey with Marc Savard's No. 91 on the back. "This is what you would call genuine front running," Francona said. The Bruins won the Stanley Cup on Wednesday night, although Savard missed much of the season and the entire playoffs following a concussion.