Guthrie will try to extend a dominant run against the White Sox when these teams close a three-game series Thursday night at Kauffman Stadium.
A 3-0 loss Wednesday dropped Chicago to 6-11 this season against Kansas City and reduced its lead in the AL Central to two games over Detroit.
Bruce Chen scattered five hits over 6 2-3 innings, Alex Gordon hit a two-run double and the White Sox went 1 for 12 with runners in scoring position as its five-game winning streak was snapped. Chicago had the bases loaded with no outs in the fourth, but failed to score.
"We're going to have to win no matter what. We have to take care of our business," manager Robin Ventura said. "It's difficult when you play like this."
It's been particularly frustrating for Chicago (81-67) against Kansas City. The White So have averaged 2.9 runs in the season series while batting .169 with runners in scoring position.
Sending Guthrie (4-3, 3.13 ERA) to the mound would seem a good way for the Royals (67-81) to continue succeeding in the role of spoiler.
The right-hander hasn't given up an earned run in 23 2-3 innings over three starts against the White Sox this season, allowing 13 hits, striking out 15 and walking one.
He went eight innings in Chicago on Sept. 9, surrendering six hits in a 2-1, 10-inning victory.
"He just mixes pitches real well and got quick outs," Chicago's Gordon Beckham said. "He's got a lot of sink on the ball."
Guthrie has been a solid pick up for the Royals, who acquired him in a trade with Colorado in July. He is 4-0 with a 1.78 ERA in his last eight starts overall, with the Royals winning each game.
The White Sox counter with Francisco Liriano (6-11, 5.24).
Liriano snapped a four-start winless streak Saturday against Minnesota, taking a no-hitter into the seventh inning before giving up a two-run homer. It was the only hit he allowed over seven innings of a 5-3 win.
The left-hander was 0-1 with a 7.71 ERA over his previous four appearances, including three starts, but struck out nine Saturday."He seemed like he was more under control, he wasn't as jumpy, he wasn't as quick," catcher A.J. Pierzynski said. "It looked like he slowed it down a little bit. He pitched really well. I was happy for him to come back here and do that. He had a great slider and a great changeup."
Liriano is 0-1 with a 5.51 ERA in three starts against the Royals this year, the first two coming with the Twins. He allowed five runs, four walks and surrendered two homers over five innings of a 7-5 loss Sept. 7 while not earning a decision.
|Chicago White Sox|
|September 07, 2012||Adam Dunn||Day-to-Day||Strained right oblique|
|August 27, 2012||Gavin Floyd||15-Day DL||Right elbow flexor strain|
|August 27, 2012||Gavin Floyd||15-Day DL||Right elbow flexor strain|
|August 25, 2012||Dayan Viciedo||Day-to-Day||Right shoulder soreness|
|August 19, 2012||Kevin Youkilis||Day-to-Day||Sore right knee|
|August 18, 2012||Alejandro De Aza||15-Day DL||Bruised left ribcage|
|Kansas City Royals|
|September 18, 2012||Luis Mendoza||Day-to-Day||Strep throat|
|September 14, 2012||Lorenzo Cain||Day-to-Day||Left game - Strained right hamstring|
|August 18, 2012||Chris Getz||15-Day DL||Broken left thumb|
|August 17, 2012||Chris Getz||Day-to-Day||Left game - fractured left thumb|
|July 28, 2012||Mike Moustakas||Day-to-Day||Left game - sprained right knee|
|July 05, 2012||Luke Hochevar||Day-to-Day||Sprained right ankle|
KANSAS CITY, Mo. (AP) -- The Chicago White Sox have no more games left against the Kansas City Royals , and that's a good thing for the AL Central leaders.
Kansas City catcher Salvador Perez threw out Alex Rios at the plate and picked off Alexei Ramirez at third base, and the White Sox kept missing chances Thursday night in a 4-3 loss to the Royals.
Eric Hosmer singled home the winning run on a 0-2 pitch with two outs in the ninth inning.
Chicago stayed two games ahead of Detroit, which lost in the afternoon to Oakland, with 13 games remaining. The White Sox went 6-12 against the Royals this year, including one stretch of six consecutive losses.
"We've played them tough all year," Hosmer said. "It's baseball. Certain teams match up well against other teams."
After going 1 for 12 with runners in scoring position in Wednesday's 3-0 loss to Kansas City, the White Sox went 1 for 8 in those situations and stranded seven runners. Chicago is hitting .190 with runners in scoring position over the past 19 games.
"If you keep shooting yourself in the foot it's going to come back to bite you," White Sox manager Robin Ventura said. "If you keep having opportunities and not taking advantage, a team like this will beat you."
Rios tried to score with one out in the third when Jeremy Guthrie 's pitch rolled a few feet behind Perez. But Perez's toss to Guthrie cut down Rios at the plate.
"Alex thinks he can go, then he hesitates," Ventura said. "That one's an instinct play, you go or you stop. It's little things like that we have to stop doing."
Rios' out became more magnified when Kevin Youkilis singled to left two pitches later.
"If you hesitate and don't get a good read, bad stuff happens when you do that," Rios said. "You have to be aware of the situation, with one out I could have scored on a fly ball. It was a tough read, a bad angle. I hesitated. I've got to go without hesitating."
Perez nabbed Ramirez in the fourth for his fifth pickoff, most among major league catchers.
"I don't know if they've got quicksand around third, but we've been losing guys over there," Ventura said.
Chicago wasted an early 3-0 lead and lost to the sub-.500 Royals for the ninth time in their last 11 meetings.
Billy Butler led off the Royals ninth with a single against Jesse Crain (2-3). Pinch-runner Jarrod Dyson stole second with two down and Jeff Francoeur was walked intentionally. Matt Thornton relieved and Hosmer singled down the third-base line.
Greg Holland (7-4) worked a scoreless ninth for the victory.
Alejandro De Aza, Adam Dunn and A.J. Pierzynski singled in the first to put the White Sox in front 1-0.
Guthrie committed a throwing error in the second that led to two unearned runs. He walked Dan Johnson and gave up an infield single to Ramirez, then made a wild throw to first on Gordon Beckham 's sacrifice that allowed a run to score. Dewayne Wise added an RBI grounder.
Guthrie allowed three runs and eight hits in six innings. The right-hander is 4-0 with a 1.75 ERA in his past nine starts, all of which the Royals have won.
"I didn't have great command or great stuff, but I relied on defensive plays," he said. "Sal made three great plays. I don't think I really settled in. Really each pitch seemed like a struggle, not many at-bats did I feel like I was in control. It was a real struggle. I didn't have a feel for much of what I was doing."
Francisco Liriano held the Royals to one hit in the first four innings, but gave up a two-run triple to Johnny Giavotella in the fifth.
"Gio's hit turned it around," Royals manager Ned Yost said. "We were doing absolutely nothing until then."
Billy Butler doubled in Alex Gordon in the sixth, tying it at 3. Butler has 99 RBIs, the most by a Royals player since Carlos Beltran 's 100 in 2003.
NOTES: White Sox 1B Paul Konerko was held out of the lineup with a sore back. Rios replaced him in the cleanup slot. ... The White Sox continue their trip with a weekend series at Los Angeles. RHP Jake Peavy will start Friday night against the Angels. He is 0-2 with a 5.04 ERA in four career starts vs. the Angels. ... RHP Luis Mendoza , who had strep throat and was scratched from a Wednesday start, will start Friday for the Royals against Cleveland. ... Perez has picked off a franchise-record eight in 104 career games. Darrell Porter held the club record with seven in 492 Royals games from 1977-80.