While Anderson looks to avoid a third straight rough start, Lester tries to remain undefeated in Wednesday's series finale.
After Oakland (13-8) scored four runs while being swept in a three-game set at Tampa Bay and lost 9-6 at Boston on Monday, Seth Smith homered and Bartolo Colon pitched seven solid innings during a rain-shortened, 13-0, seven-inning rout Tuesday.
The A's took advantage of eight walks, two balks and two errors by the Red Sox (13-7) to post a much-needed victory. John Jaso and Brandon Moss each had three hits with two RBIs for Oakland, which has scored a major league-leading 119 runs.
Boston, meanwhile, has dropped three of four after it won seven in a row.
"The weather conditions weren't ideal, but to say that it was a major distraction, I don't know that we can go that far. We see what Bartolo did against us," Red Sox manager John Farrell said.
Former Boston outfielder Coco Crisp added two hits with two RBIs after going 1 for 10 in three contests following a 12-game hitting streak.
Looking for a 10th win in 11 games versus Boston, the A's will try to get the best of Lester (3-0, 1.73 ERA).
The left-hander has not allowed a homer and struck out 23 in 26 innings in four starts. He gave up two runs and four hits in seven innings of a 6-3 win at Cleveland on Thursday.
"Lester has a lot of ways to attack hitters," his former manager and current Cleveland skipper Terry Francona told the Red Sox's official website. "Whether it's depth on his two-seamer or life on the fastball, and then he's got that cutter. And he threw an occasional breaking ball. He has a lot of ways of opening up the plate."
Lester is 3-3 with a 4.15 ERA in 10 starts versus Oakland, which hopes Anderson (1-3, 5.95) can get back on track after two straight rough outings and improve on his 5-2 mark and 2.70 ERA in eight starts against the Red Sox.
The left-hander yielded two runs in each of his first two starts but allowed 11 and walked five while striking out three in 6 2-3 innings to lose his last two. He gave up four runs in the first inning of an 8-3 loss at Tampa Bay on Friday before leaving with a sprained ankle.
Anderson, however, appears healthy to return to the mound Wednesday.
"I can obviously feel it a little bit when running," Anderson told the Athletics' official website. "Other than that, it feels good."
Batting .308 (4 for 13) with a double against Anderson, David Ortiz had one of Boston's three hits off Colon. Ortiz is 6 for 12 in three games since starting the season on the disabled list with an Achilles injury.
|April 19, 2013||Brett Anderson||Day-to-Day||Ankle|
|April 13, 2013||Yoenis Cespedes||15-Day DL||Strained muscle, left hand|
|April 12, 2013||Coco Crisp||Day-to-Day||Strained left groin|
|April 10, 2013||Scott Sizemore||60-Day DL||Torn left ACL - out for season|
|April 07, 2013||Josh Reddick||Day-to-Day||Sprained right wrist|
|March 27, 2013||Hiroyuki Nakajima||15-Day DL||Strained left hamstring|
|Boston Red Sox|
|April 20, 2013||Shane Victorino||Day-to-Day||Left game - lower back tightness|
|April 14, 2013||Joel Hanrahan||15-Day DL||Sore right hamstring|
|April 07, 2013||John Lackey||15-Day DL||Right biceps strain|
|April 06, 2013||John Lackey||Day-to-Day||Left game - Right biceps strain|
|March 27, 2013||Stephen Drew||7-Day DL||Concussion|
|March 27, 2013||Stephen Drew||7-Day DL||Concussion|
BOSTON (AP) -- Big Papi almost looks as if he never missed all that time.
David Ortiz had two hits and drove in a run, Stephen Drew hit a two-run triple, and the Boston Red Sox beat the Oakland Athletics 6-5 on Wednesday afternoon to take a three-game series.
"When you consider eight months down and I don't know how many at-bats he's had, 15 or so and you consider the number of hits he's compiled, it is impressive," Red Sox manager John Farrell said. "He's got such good plate coverage. Against lefties he goes the other way for a double and hits one through the hole.
"He's pretty amazing to watch and he's run the bases well. There's no issues as far as his intensity as well - as he's run with. He's really given us a lift in the middle of the order."
It was Boston's ninth win in 12 games and came after a 13-0 loss to Oakland a night earlier.
Ortiz is 8 for 16 since returning to the lineup on Saturday for the first time since last August. He missed 71 of the final 72 games last season and all of spring training's with an Achilles tendon injury.
But he doesn't feel that well yet.
"I'm not really concerned with getting injured," he said. "But there's still some concern because I'm not 100 percent yet."
Ortiz has multiple hits in three of his four games.
"I work, man. I work. I'm old enough to know what I need to do to stay there," he said. "Right now I'm not where I want to be, so I'm not trying to juice some balls. I'm trying to stay with what they give me. You see how they pitch me. I got to be patient."
Chris Young had a three-run homer and a solo shot for the Athletics, who finished a six-game road trip 1-5. They were swept at the Tampa Bay Rays over the weekend.
Jon Lester (4-0) got the win despite walking a season-high six and lasting just 5 2-3 innings. He allowed three runs on six hits, striking out five and walking two more than he had in his previous four starts.
Oakland was hurt by another rough start by Brett Anderson .
Anderson (1-4) was hit hard for the third straight start, giving up six runs on eight hits in four-plus innings. In the last three, he's been tagged for 17 runs in 10 2-3 innings.
"It just seems like he's out of sync at times," manager Bob Melvin said. "Just for whatever reasons at times, he loses his command, he gets behind. It looked like that was a little bit of the issue today."
Anderson just feels like he needs to do anything to change his luck.
"I've just got to go out there and maybe help a grandma cross a street or burn my locker or something like that," he said, "and get some better mojo going, because I'm a better pitcher than that."
Andrew Bailey struck out all three batters in the ninth for his fifth save.
It was Lester's 89th career win, matching Babe Ruth for fifth in club history by left-handers.
The Red Sox broke a 3-all tie and chased Anderson with a three-run fifth. Jacoby Ellsbury opened the inning with an infield hit and scored on Shane Victorino 's double. Dustin Pedroia reached on an infield hit and Ortiz followed with an RBI single. Chris Resop relieved and hit Mike Napoli with the first pitch before Daniel Nava had a pinch-hit single. After Will Middlebrooks flied out, Jerry Blevins entered and retired the final two batters, leaving the bases loaded.
Lester was pulled with the bases loaded and in the sixth, but Junichi Tazawa got Coco Crisp to fly out.
Josh Donaldson 's RBI single made it 6-4 and Young's second homer cut it to one in the eighth.
The Athletics went ahead with three runs against Lester in the fourth on Young's homer that caromed off a billboard above the Green Monster seats, but Boston tied it with three in the bottom of the inning.
Ortiz, back in the lineup after getting Tuesday off, doubled leading off and scored on Napoli's double. Jonny Gomes walked and, one out later, Drew tripled into the right-field corner.
NOTES: Boston optioned RHP Alfredo Aceves to Triple-A Pawtucket after the game. He allowed eight runs in 3 1-3 innings on Tuesday night. ... Anderson had left his previous start with a sprained right ankle. ... Melvin said he kept Josh Reddick out of the starting lineup with a tough lefty going now that it looks like the outfielder's worked out of a slump. Reddick was 2 for 4 in each of the first two games after going just 3 for 37 in the previous 10. Reddick struck out pinch hitting. ... Boston recalled RHP Daniel Bard from Double-A Portland before the game and optioned RHP Steven Wright to Triple-A Pawtucket. ... The Red Sox again honored members of the Watertown, Mass., police department. Members stood on top of both dugouts, got a big ovation from fans and both teams. ... Home plate umpire Jerry Layne left the game after being hit on the left hand by a foul tip in the third. Second base ump Mike Estabrook took over behind the plate. ... Anderson was 5-2 with a 2.70 ERA in eight starts against Boston. ... A fan was taken from the stands on a stretcher in the ninth. ... Victorino left in the seventh when his back stiffened up