The right-hander has completely shut down Chicago since being acquired by the Royals last summer, and he'll look to add to the visiting White Sox's woes in the opener of a three-game series Friday night.
Guthrie came to Kansas City in a deal for left-hander Jonathan Sanchez on July 19, and he's gone 3-0 with a 0.40 ERA in six starts against the White Sox. The Royals have won all six games, and Guthrie has allowed one run over 15 innings in winning both outings this season.
He pitched a four-hitter in his first career shutout in the last matchup May 4, walking one in a 2-0 victory in Kansas City.
"He's been tough on us," White Sox manager Robin Ventura said. "First, because he's good. ... He seems to pick it up when we're facing him. ... You have to pick your poison, you go after him early and then you pop it up. He's tough."
Guthrie beat Baltimore in his next start May 9 to increase his club record to 18 consecutive outings without a defeat and improve to 5-0 with a 2.28 ERA on the season. However, he's struggled since, going 2-4 with a 5.24 ERA in his past seven starts.
Guthrie (7-4, 3.72 ERA) gave up three home runs in a 5-3 loss at Tampa Bay on Saturday and leads the majors with 19 allowed.
"I'd like someone to pass me," Guthrie told the Royals' official website. "It's hard for them to pass me, I'm going real fast."
Guthrie has not allowed a home run in 44 2-3 innings against the White Sox (29-41) since joining the Royals (34-36).
Chicago has dropped three straight, seven of eight and 17 of 22 games. The White Sox are 12 games under .500 for the first time since the last day of the 2007 season.
"We truly feel like we're way too good to be playing like this," pitcher John Danks said. "We feel we're just as talented as any team in the league."
The Royals are 12-6 in June but have lost two in a row, falling 6-3 in Cleveland on Wednesday night.
"It's tough," left fielder Alex Gordon said. "... We would have loved to turn these last two games around. We could have. We had our opportunities and just didn't do it."
Kansas City will be facing Hector Santiago (2-5, 3.30), who has been filling in for the injured Jake Peavy . The left-hander has been in and out of the rotation this season, going 2-3 with a 3.00 ERA in seven starts.
He lost 5-4 in Houston on Sunday after giving up three runs in the second inning.
"Like I said earlier in the year, it's always one inning," Santiago told the White Sox's official website. "First, second inning I get in trouble and then I settled in, but I have to get to the point where I get through the first two innings. Get through those and it seems like we're good from there."
Santiago has not allowed a run while striking out 13 in 11 1-3 career innings against the Royals. He's made one start, allowing three hits in four innings opposite Guthrie on Sept. 9 when the Royals won 2-1 in 10 innings in Chicago.
|Alejandro De Aza||13||.385||5||0||1||0||2||.385||.847||.462|
|Chicago White Sox|
|June 15, 2013||Alejandro De Aza||Day-to-Day||Illness|
|June 05, 2013||Jake Peavy||15-Day DL||Fractured rib - out 4-6 weeks|
|June 04, 2013||Jake Peavy||Day-to-Day||Left game - Rib pain|
|May 30, 2013||Dewayne Wise||15-Day DL||Strained right hamstring|
|May 22, 2013||Chris Sale||Day-to-Day||Left shoulder tendinitis|
|May 02, 2013||Dewayne Wise||Day-to-Day||Stiff neck|
|Kansas City Royals|
|May 16, 2013||Jarrod Dyson||15-Day DL||Right ankle sprain|
|March 31, 2013||Danny Duffy||60-Day DL||Recovery from left elbow surgery|
|February 12, 2013||Felipe Paulino||60-Day DL||Recovery from right elbow surgery|
KANSAS CITY, Mo. (AP) -- Once the Chicago White Sox had put two runs on the board - it took them all of one inning - it was up to Hector Santiago to simply pour strikes into the zone.
The Kansas City Royals ' punchless offense couldn't touch him.
Santiago wound up pitching a career-best eight innings, and long home runs by Dayan Viciedo and Alejandro De Aza turned Friday night's game into a 9-1 rout by the White Sox.
"Getting ahead early and getting the lead, we just kept putting on and putting on," said Santiago, who has taken over injured starter Gavin Floyd 's spot in the rotation.
"You want to go out every inning and show them you're fighting," he said. "They score runs and you want to get them back in so they keep scoring."
Viciedo's three-run shot capped a five-run third inning, and De Aza's two-run homer in the sixth put the game away. Tyler Flowers was the only member of the White Sox starting lineup without a hit against Jeremy Guthrie , reliever Bruce Chen and the Royals' roughed-up bullpen.
"It was a good first inning," Chicago manager Robin Ventura said, "and I think the approach all night, and against those two guys, having Guthrie and Chen in there at the same time, as tough as they've been on us, you're exorcising some curse or something. It was good."
It was easily Santiago's best performance since going seven scoreless innings May 7 against the New York Mets . It also helped the scuffling White Sox get back on track after losing 17 of 22 and dropping a season-high 12 games below .500.
The left-hander gave up just three hits and a walk, and Eric Hosmer 's homer in the sixth represented the only run Santiago (3-5) has allowed to the Royals in 19 1-3 career innings.
"He got that early lead. He was pounding the strike zone and letting his defense do the work," Hosmer said. "He had a lot of run support and he was feeling confident. When you have that lead you can tell the hitter, `Here it is. Hit it."'
On a warm, windy night at Kauffman Stadium, Guthrie (7-5) walked three of the first five batters he faced, and the bases-loaded free pass that he issued to Paul Konerko brought in the game's first run. Conor Gillaspie added a sacrifice fly later in the first to make it 2-0.
The real trouble for Guthrie came in the third, when Alexei Ramirez led off with a single and Alex Rios doubled over the head of Alex Gordon in left field. Adam Dunn 's single drove in another run, and Gillaspie's single knocked Guthrie from the game.
Viciedo greeted Chen with a three-run shot to give the White Sox a 7-0 lead.
"I just couldn't find the strike zone," Guthrie said. "I created a mess in the first inning and gave up a bunch of base hits in the third."
Guthrie wound up allowing six runs on five hits and three walks in 2 1-3 innings, his shortest start since going the same distance for the Orioles on July 7, 2009. It was his second straight shaky outing, too - he allowed five runs over seven innings Saturday night at Tampa Bay.
All the more puzzling is that Guthrie had been having success against the White Sox. Since joining the Royals last year, the right-hander had been 3-0 in six starts against their AL Central rivals, giving up just two earned runs in 44 2-3 innings.
Guthrie had given up that many Friday night before escaping the first inning.
"He just didn't have it," Royals manager Ned Yost said. "It was one of those nights when he didn't have much going for him."
De Aza's two-run homer in the sixth made it 9-0, the most runs that the Royals' stingy pitching staff had allowed since an 11-6 loss to the New York Yankees on May 10. It was also the most runs the White Sox had scored since beating Toronto 10-6 on June 10.
"That's how this team is, going back to last year," Dunn said. "But you could see it, a little sigh of relief. You get a couple hits and you get a little excitement on the bench."
NOTES: The White Sox recalled RHP Brian Omogross from Triple-A Charlotte before the game. ... Major League Baseball announced the Royals will make up their May 2 game against Tampa Bay that was snowed out on Aug. 26 at Kauffman Stadium. The first pitch will be at 1:10 p.m. CT. ... LHP Jose Quintana takes the mound Saturday against Royals RHP Wade Davis .