BOSTON (Ticker) -- A historic moment at Fenway Park turned out to be the key to victory for the Boston Red Sox .

Kevin Millar 's two-run homer in the bottom of the eighth inning was the 10,000th in the history of Fenway Park, capping a three-run frame and leading the Red Sox to a 6-4 triumph over the Baltimore Orioles .

With runners on the corners and none out in the eighth inning of a 3-3 game, a wild pitch by Travis Driskill (3-5) allowed pinch runner Damian Jackson to race home with the go-ahead run. Two pitches later, Millar lifted a shot over the "Green Monster" in left field to give Boston a 6-3 lead.

"I had no clue until afterwards," Millar said of the importance of the homer. "I was also Randy Johnson 's 300th strikeout back-to-back years. That's hard to do also!"

"(Surrendering the) 10,000th home run ever, sweet! I got my name in the record book," Driskill joked. "It was a hanging split and you saw what happened on that one. ... I bounced a split and hung a split. That's how three runs score."

The blast made Fenway Park just the fourth ballpark in major league history to yield 10,000 home runs, joining Tiger Stadium in Detroit, Wrigley Field in Chicago and Yankee Stadium in New York. The historical shot came in the 7,101st game at Fenway since 1912.

Millar's 19th homer made a winner of Alan Embree (4-1), who retired the only batter he faced in the eighth. Byung-Hyun Kim notched his ninth save despite allowing a run and two hits in the ninth.

Manny Ramirez belted his 100th homer as a member of the Red Sox , becoming just the 25th player in team history to reach the plateau and second in as many days. Trot Nixon joined the group in the first game of Friday's doubleheader.

Driskill started the eighth in relief of starter Damian Moss , who allowed three runs and six hits in seven innings. He was greeted with singles by Ramirez and David Ortiz , putting runners on the corners.

"Here's a guy who's one of the premier power hitters in the game and he took a fastball up, out over the plate and drove it into right field for a base hit," Orioles manager Mike Hargrove said. "That's as good a piece of hitting as you'll ever see. It progressed from there."

After Driskill's wild pitch plated Jackson, Millar launched his 19th homer on a 2-2 pitch for a three-run bulge.

"I was given a good opportunity tonight, with the game tied, to pitch in a crucial situation and I haven't gotten to do that in a while, and I dropped the ball tonight," Driskill said.

"Travis was the only fresh arm we had in the bullpen going into tonight," Hargrove said. "I'm not offering that as an excuse. Travis is a major league pitcher, he gets people out. He just didn't have it going tonight."

Boston scored twice against Moss in the third inning to take the lead. Todd Walker led off the frame with a double and Doug Mirabelli walked.

Johnny Damon loaded the bases with a bunt single, and Bill Mueller stroked a double to left-center to plate Walker and Mirabelli for a 2-0 cushion.

Baltimore responded with three runs in the fourth to move ahead. With one out, Luis Matos tripled and scored on a single by Jay Gibbons . Tony Batista followed with his 20th homer, giving the Orioles a 3-2 lead.

The Red Sox threatened in the fourth, when Millar drew a leadoff walk and moved to third on a sacrifice and a groundout. But Moss induced a groundout by Mirabelli to preserve the one-run advantage.

"I shouldn't even be in that predicament in the first place," Moss said. "If I make quality pitches, I'm not in that situation. As far as getting out of it, it's a positive, but I shouldn't be in that situation."

Ramirez erased the deficit in the sixth, opening the inning with a blast over the left field wall on a 2-2 offering to reach the 100-homer mark faster than any player in Boston history. He accomplished the feat in 1,388 at-bats, two fewer than Jimmie Foxx .

The homer also prevented Boston from going consecutive games without one for the first time since June 14-15.

"This wall here in Fenway Park is a big asset for these type of hitters, and they are taking advantage," Boston manager Grady Little said.

Kim retired the first two Orioles he faced in the ninth before running into trouble.

Brook Fordyce swatted his third homer of the season to cut Baltimore's deficit to 6-4, and Larry Bigbie reached on an infield single. After a fielder's indifference, Jose Leon walked to bring the go-ahead run to the plate. But Kim got Brian Roberts to ground out to end the game.

Boston starter Tim Wakefield tossed 7 2/3 frames, moving him ahead of George Winter for seventh place on the club's all-time list with 1,605 1/3 innings pitched.