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Updated: Sunday March 31, 7:01 AM
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| Rank | Player | Team | ERA | W | L | S | SvO | G | GS | CG | SO | IP | H | R | ER | HR | BB | K | QS | Ratio | BAVG |
| 1 | Clayton Kershaw | LAD | 2.53 | 14 | 9 | 0 | 0 | 33 | 33 | 2 | 2 | 227.2 | 170 | 70 | 64 | 16 | 63 | 229 | 0 | 1.02 | .210 |
| 2 | Matt Cain | SF | 2.79 | 16 | 5 | 0 | 0 | 32 | 32 | 2 | 2 | 219.1 | 177 | 73 | 68 | 21 | 51 | 193 | 0 | 1.04 | .222 |
| 3 | R.A. Dickey | NYM | 2.73 | 20 | 6 | 0 | 0 | 34 | 33 | 5 | 3 | 233.2 | 192 | 78 | 71 | 24 | 54 | 230 | 0 | 1.05 | .226 |
| 4 | Kyle Lohse | STL | 2.86 | 16 | 3 | 0 | 0 | 33 | 33 | 0 | 0 | 211 | 192 | 74 | 67 | 19 | 38 | 143 | 0 | 1.09 | .239 |
| 5 | Madison Bumgarner | SF | 3.37 | 16 | 11 | 0 | 0 | 32 | 32 | 2 | 1 | 208.1 | 183 | 87 | 78 | 23 | 49 | 191 | 0 | 1.11 | .234 |
| Cliff Lee | PHI | 3.16 | 6 | 9 | 0 | 0 | 30 | 30 | 0 | 0 | 211 | 207 | 79 | 74 | 26 | 28 | 207 | 0 | 1.11 | .255 | |
| 7 | Cole Hamels | PHI | 3.05 | 17 | 6 | 0 | 0 | 31 | 31 | 2 | 2 | 215.1 | 190 | 80 | 73 | 24 | 52 | 216 | 0 | 1.12 | .237 |
| 8 | Gio Gonzalez | WAS | 2.89 | 21 | 8 | 0 | 0 | 32 | 32 | 2 | 1 | 199.1 | 149 | 69 | 64 | 9 | 76 | 207 | 0 | 1.13 | .206 |
| 9 | Mike Minor | ATL | 4.12 | 11 | 10 | 0 | 0 | 30 | 30 | 0 | 0 | 179.1 | 151 | 88 | 82 | 26 | 56 | 145 | 0 | 1.15 | .232 |
| 10 | Mat Latos | CIN | 3.48 | 14 | 4 | 0 | 0 | 33 | 33 | 2 | 0 | 209.1 | 179 | 87 | 81 | 25 | 64 | 185 | 0 | 1.16 | .230 |
| 11 | Mark Buehrle | MIA | 3.74 | 13 | 13 | 0 | 0 | 31 | 31 | 1 | 0 | 202.1 | 197 | 88 | 84 | 26 | 40 | 125 | 0 | 1.17 | .258 |
| Johnny Cueto | CIN | 2.78 | 19 | 9 | 0 | 0 | 33 | 33 | 2 | 0 | 217 | 205 | 73 | 67 | 15 | 49 | 170 | 0 | 1.17 | .252 | |
| Jonathon Niese | NYM | 3.40 | 13 | 9 | 0 | 0 | 30 | 30 | 0 | 0 | 190.1 | 174 | 77 | 72 | 22 | 49 | 155 | 0 | 1.17 | .241 | |
| Jordan Zimmermann | WAS | 2.94 | 12 | 8 | 0 | 0 | 32 | 32 | 0 | 0 | 195.2 | 186 | 69 | 64 | 18 | 43 | 153 | 0 | 1.17 | .251 | |
| 15 | Wade Miley | ARI | 3.33 | 16 | 11 | 0 | 0 | 32 | 29 | 0 | 0 | 194.2 | 193 | 79 | 72 | 14 | 37 | 144 | 0 | 1.18 | .255 |
| 16 | Bronson Arroyo | CIN | 3.74 | 12 | 10 | 0 | 0 | 32 | 32 | 1 | 1 | 202 | 209 | 86 | 84 | 26 | 35 | 129 | 0 | 1.21 | .267 |
| Tim Hudson | ATL | 3.62 | 16 | 7 | 0 | 0 | 28 | 28 | 1 | 1 | 179 | 168 | 77 | 72 | 12 | 48 | 102 | 0 | 1.21 | .248 | |
| 18 | Chris Capuano | LAD | 3.72 | 12 | 12 | 0 | 0 | 33 | 33 | 0 | 0 | 198.1 | 188 | 91 | 82 | 25 | 54 | 162 | 0 | 1.22 | .254 |
| Ross Detwiler | WAS | 3.40 | 10 | 8 | 0 | 0 | 33 | 27 | 0 | 0 | 164.1 | 149 | 75 | 62 | 15 | 52 | 105 | 0 | 1.22 | .241 | |
| Edwin Jackson | WAS | 4.03 | 10 | 11 | 0 | 0 | 31 | 31 | 1 | 0 | 189.2 | 173 | 90 | 85 | 23 | 58 | 168 | 0 | 1.22 | .243 | |
| Paul Maholm | ATL | 3.67 | 13 | 11 | 0 | 0 | 32 | 31 | 1 | 1 | 189 | 178 | 80 | 77 | 20 | 53 | 140 | 0 | 1.22 | .250 | |
| Jeff Samardzija | CHC | 3.81 | 9 | 13 | 0 | 0 | 28 | 28 | 1 | 0 | 174.2 | 157 | 79 | 74 | 20 | 56 | 180 | 0 | 1.22 | .240 | |
| 23 | Clayton Richard | SD | 3.99 | 14 | 14 | 0 | 0 | 33 | 33 | 1 | 1 | 218.2 | 228 | 110 | 97 | 31 | 42 | 107 | 0 | 1.23 | .267 |
| Ryan Vogelsong | SF | 3.37 | 14 | 9 | 0 | 0 | 31 | 31 | 0 | 0 | 189.2 | 171 | 76 | 71 | 17 | 62 | 158 | 0 | 1.23 | .242 | |
| 25 | Homer Bailey | CIN | 3.68 | 13 | 10 | 0 | 0 | 33 | 33 | 2 | 1 | 208 | 206 | 97 | 85 | 26 | 52 | 168 | 0 | 1.24 | .256 |
| A.J. Burnett | PIT | 3.51 | 16 | 10 | 0 | 0 | 31 | 31 | 1 | 1 | 202.1 | 189 | 86 | 79 | 18 | 62 | 180 | 0 | 1.24 | .246 | |
| 27 | Adam Wainwright | STL | 3.94 | 14 | 13 | 0 | 0 | 32 | 32 | 3 | 2 | 198.2 | 196 | 96 | 87 | 15 | 52 | 184 | 0 | 1.25 | .259 |
| 28 | Joe Blanton | LAD | 4.71 | 10 | 13 | 0 | 0 | 31 | 30 | 2 | 1 | 191 | 207 | 106 | 100 | 29 | 34 | 166 | 0 | 1.26 | .273 |
| James McDonald | PIT | 4.21 | 12 | 8 | 0 | 0 | 30 | 29 | 1 | 0 | 171 | 147 | 85 | 80 | 21 | 69 | 151 | 0 | 1.26 | .233 | |
| 30 | Wandy Rodriguez | PIT | 3.76 | 12 | 13 | 0 | 0 | 34 | 33 | 0 | 0 | 205.2 | 205 | 99 | 86 | 21 | 56 | 139 | 0 | 1.27 | .255 |
| 31 | Josh Johnson | MIA | 3.81 | 8 | 14 | 0 | 0 | 31 | 31 | 0 | 0 | 191.1 | 180 | 84 | 81 | 14 | 65 | 165 | 0 | 1.28 | .252 |
| 32 | Trevor Cahill | ARI | 3.78 | 13 | 12 | 0 | 0 | 32 | 32 | 2 | 1 | 200 | 184 | 93 | 84 | 16 | 74 | 156 | 0 | 1.29 | .250 |
| 33 | Kevin Correia | PIT | 4.21 | 12 | 11 | 0 | 0 | 32 | 28 | 0 | 0 | 171 | 176 | 89 | 80 | 20 | 46 | 89 | 0 | 1.30 | .267 |
| Yovani Gallardo | MIL | 3.66 | 16 | 9 | 0 | 0 | 33 | 33 | 0 | 0 | 204 | 185 | 86 | 83 | 26 | 81 | 204 | 0 | 1.30 | .243 | |
| Ian Kennedy | ARI | 4.02 | 15 | 12 | 0 | 0 | 33 | 33 | 1 | 0 | 208.1 | 216 | 101 | 93 | 28 | 55 | 187 | 0 | 1.30 | .266 | |
| 36 | Lance Lynn | STL | 3.78 | 18 | 7 | 0 | 0 | 35 | 29 | 0 | 0 | 176 | 168 | 76 | 74 | 16 | 64 | 180 | 0 | 1.32 | .253 |
| 37 | Josh Beckett | LAD | 4.65 | 7 | 14 | 0 | 0 | 28 | 28 | 0 | 0 | 170.1 | 174 | 91 | 88 | 21 | 52 | 132 | 0 | 1.33 | .264 |
| 38 | Mike Leake | CIN | 4.58 | 8 | 9 | 0 | 0 | 30 | 30 | 2 | 0 | 179 | 201 | 97 | 91 | 26 | 41 | 116 | 0 | 1.35 | .287 |
| 39 | Ricky Nolasco | MIA | 4.48 | 12 | 13 | 0 | 0 | 31 | 31 | 3 | 2 | 191 | 214 | 100 | 95 | 18 | 47 | 125 | 0 | 1.37 | .285 |
| 40 | Jake Westbrook | STL | 3.97 | 13 | 11 | 0 | 0 | 28 | 28 | 1 | 0 | 174.2 | 191 | 85 | 77 | 12 | 52 | 106 | 0 | 1.39 | .282 |
| Barry Zito | SF | 4.15 | 15 | 8 | 0 | 0 | 32 | 32 | 1 | 1 | 184.1 | 186 | 91 | 85 | 20 | 70 | 114 | 0 | 1.39 | .263 | |
| 42 | Aaron Harang | LAD | 3.61 | 10 | 10 | 0 | 0 | 31 | 31 | 0 | 0 | 179.2 | 167 | 85 | 72 | 14 | 85 | 131 | 0 | 1.40 | .246 |
| 43 | Tommy Hanson | ATL | 4.48 | 13 | 10 | 0 | 0 | 31 | 31 | 0 | 0 | 174.2 | 183 | 95 | 87 | 27 | 71 | 161 | 0 | 1.45 | .271 |
| Edinson Volquez | SD | 4.14 | 11 | 11 | 0 | 0 | 32 | 32 | 1 | 1 | 182.2 | 160 | 88 | 84 | 14 | 105 | 174 | 0 | 1.45 | .236 | |
| 45 | Tim Lincecum | SF | 5.18 | 10 | 15 | 0 | 0 | 33 | 33 | 0 | 0 | 186 | 183 | 111 | 107 | 23 | 90 | 190 | 0 | 1.47 | .257 |
