BIRMINGHAM, Alabama (Ticker) -- No. 4 seed Louisville hopes to avoid becoming the second straight higher-ranked team to lose to 12th-seeded Butler when they match up in the second round of the NCAA Tournament East Region on Sunday.
The Bulldogs (26-5) upset No. 5 seed Mississippi State on Friday, 47-46. Brandon Miller, who paced Butler with 14 points, hit a floater in the lane with 6.2 seconds left for the go-ahead basket.
Duane Lightfoot added 13 points for Butler, which shot just 38 percent but limited Mississippi State to 36 percent.
Louisville (25-6) routed Austin Peay in its first-round matchup on Friday, 86-64.
Luke Whitehead contributed 20 points and 11 rebounds and Reece Gaines added 18 points for the Cardinals, who shot 50 percent.
It was the first NCAA Tournament game for Rick Pitino since his Kentucky squad lost in the 1997 national title game to Arizona.
Louisville is 4-4 all time against Butler. The teams last met on December 8, 1973, with the Cardinals posting a 74-65 victory.
They have never met in an NCAA Tournament before.
"Their offense was the same as it has been all year," Pitino said of Butler on Saturday. "The only thing they did (Friday) night that was different was they played zone last night for the first time and they played it well. The game (Sunday) won't be quite as slow as it was (Friday) night. Neither one of us has had time to prepare for each other. The scariest thing about them is not the tempo they set and play, but the four seniors and one junior they have."
"Louisville likes to pressure teams so it'll be important for us to take care of the basketball," Miller said. "It's our No. 1 concern going into the game tomorrow. You have to read what the defense gives you, and, if the right guy is shooting it, we'll be fine."