Hayes scored a career-high 32 points and Ezra Williams added 21 as the 22nd-ranked Bulldogs increased their Southeastern Conference winning streak to four games with an 89-82 victory over struggling Mississippi.
Hayes nailed six 3-pointers and Williams hit three as the Bulldogs (17-7, 9-4 SEC East) won their fourth straight against the Rebels.
"We are a good one-two punch," Hayes said. "We motivate each other and feed off each other. When he does well, I do well. And when I do well, he does well, too."
Hayes, the reigning SEC Player of the Week, recorded his previous career best on March 15, 2002, when he scored 31 against Murray State in the first round of the NCAA Tournament.
"It was just one of those nights when the shots were falling my way," Hayes said. "It was a tough game, especially in the first half. We were able to get a lead and get a win on the road in the SEC, which is tough."
The 6-7 forward has been red hot, averaging 27 points in his last three games. Hayes scored 26 against South Carolina on Saturday and 23 at Alabama on February 18.
Williams also has found his scoring touch, averaging 17.2 points in the last four games after shooting 5-for-21 in his previous two outings.
"We have to credit our offense for tonight's win," Georgia coach Jim Harrick said. "Our defense has done well the past three games, but I really have to hand it to our offense."
The Bulldogs shot a robust 57 percent (31-of-54), including Hayes' 12-of-19 performance. Georgia made 10-of-22 from beyond the arc.
Chris Daniels contributed 13 points on 5-of-6 shooting and nine rebounds, and Rashad Wright chipped in 11 and nine assists as Georgia completed a sweep of West Division opponents and moved two games ahead of Tennessee for third place in the East.
Derrick Allen paced Mississippi with 17 points on 7-of-11 shooting, but the Rebels lost their eighth straight since a 73-54 victory over Arkansas on January 25.
"I really appreciate the effort we got from our guys tonight," Mississippi coach Rod Barnes said. "Georgia is just a good team. Jarvis Hayes and Ezra Williams are probably the two best players on the same team that I've seen since I have started coaching here."
Justin Reed scored 16 points and David Sanders added 13 for Ole Miss, which shot 50 percent (34-of-68) and was simply outgunned.
Georgia improved to 62-34 against Mississippi in their all-time series, which dates to 1928.