LAWRENCE, Kansas (Ticker) -- With the game on the line, Wayne Simien and Aaron Miles handled the pressure for Kansas.
Simien scored 18 points and Miles added eight assists as the 17th-ranked Jayhawks extended their Big 12 Conference home winning streak to 22 games with a 65-56 triumph over arch rival Missouri.
Kansas (14-4, 6-1 Big 12) was never able to shake Missouri, which was bidding for consecutive wins for the first time since opening the season with a 3-0 mark. Jimmy McKinney's layup cut the Tigers' deficit to 53-52 with just under six minutes to go.
Miles made sure the Jayhawks went inside to Simien - who scored 16 points after halftime - on three of the next four possessions.
Simien delivered a pair of free throws, an inside hoop and an alley-oop slam off a perfect lob by Miles as Kansas used an 8-2 spurt to build a 61-54 advantage with 3:26 remaining.
"It was big," Kansas swingman Keith Langford said. "He came in and scored some buckets and grabbed some rebounds. He just asserted himself against a real good player in Arthur (Johnson)."
Missouri (9-9, 4-4) managed only two baskets in the final 5:59. Leading scorer Rickey Paulding was held without a point in that span.
"We had a stretch where I thought that we executed well, but at times we couldn't convert," said Missouri coach Quin Snyder, who screamed at his team in a loud morning shootaround. "During that three- or four-minute stretch, they were able to take control of the game."
The Tigers, held to their lowest point total, have alternated wins and losses in their last 10 games. As the game wound down, they were taunted by the crowd at Allen Fieldhouse with chants of, "NIT! NIT!"
Kansas struggled to create any pace in the first half and also had trouble getting the ball inside. That allowed Missouri to stay close and the Jayhawks held a 29-27 lead at halftime.
"We didn't get a chance to get out and run much," Kansas coach Bill Self said. "In games like this, there are not going to be easy baskets."
Led by Miles, Kansas slowly got untracked offensively and shot 52 percent (13-of-25) in the second half. Miles and freshman J.R. Giddens each added 11 points and the Jayhawks had 18 assists to just eight for the Tigers.
"Aaron is the heart and soul of this team," Simien said. "He is one of the major leaders and he runs the show."
Missouri played without starting point guard Randy Pulley, suspended by Snyder for the second straight game, and reserve freshman forward Linas Kleiza, who was out due to a shoulder problem. That forced the starters into extended minutes. Thomas Gardner was 1-of-9 for three points.
The see-saw game featured 17 lead changes and eight ties.