LOUISVILLE, Kentucky (Ticker) -- Maybe now Rick Pitino thinks his team is struggling.
Quemont Greer scored five of his 19 points in overtime as DePaul sent No. 21 Louisville to its fourth straight defeat, 60-58, in a Conference USA matchup.
Pitino insisted that Louisville (17-6, 7-6 C-USA) was not struggling after an overtime defeat at Cincinnati on Saturday. But his Cardinals turned in another sub-par performance that resulted in their sixth loss in seven games.
Greer's jumper with 3:09 remaining gave DePaul (16-8, 9-4) the lead for good at 59-58. Drake Diener split a pair at the line with 11 seconds to go for the final margin.
Louisville had one last chance to win the game, but Larry O'Bannon lost control of the ball in the final seconds.
"We had a totally different thing designed," Pitino said. "I didn't comprehend what we were doing. I can assure you it wasn't the play you saw."
The Cardinals, who allowed the Blue Demons to hold a 47-29 edge on the glass, fell into a sixth-place tie with Saint Louis in the conference.
"One of the reasons we are losing is that we are getting killed on the boards," Pitino said. "When you get outrebounded like we did, you are going to lose. It's been every game of late."
The Blue Demons, who have won six of seven, ended a nine-game road skid against the Cardinals. DePaul climbed into a tie for fourth with Alabama-Birmingham.
"To come into this building and win despite missing free throws really makes me proud of our team's effort," DePaul coach Dave Leitao said. "We just hung tough and it wasn't a great game, but it wasn't pretty."
Francisco Garcia, who scored 19 points, gave Louisville a 47-40 lead on two free throws with 6:19 left in regulation. DePaul fought back and finally went ahead on Andre Brown's jumper with 19 seconds remaining in the second half.
Garcia's two free throws seven seconds later put the Cardinals back on top, but Greer drove and was fouled with two seconds to go. He split his pair to send the game into overtime.
"He's got a mentality that I love," Leitao said. "He's a tough kid, he was a tight end in high school and he creates a matchup problem because when you put him at the four, he can dribble around you and he can post you up."
Louisville's execution in overtime was abysmal. The Cardinals committed four turnovers in the final 2:01, including one by Garcia with 41 seconds to go.