SEATTLE (Ticker) -- Gonzaga was ambushed in its own backyard.
Tenth-seeded Nevada used an early blitz to blow out the second-seeded Bulldogs, 91-72, in a second-round game of the St. Louis Region at KeyArena.
The loss snapped a 21-game winning streak for Gonzaga, which was projected as a potential Final Four team. But the Bulldogs were overpowered in the first half, falling behind by as many as 20 points on three occasions, and never recovered.
Nevada coach Trent Johnson was not surprised after the Wolf Pack (25-8) advanced to the "Sweet 16" for the first time in school history.
"I thought these guys to my right did a heckuva job from start to finish," Johnson said. "They stepped up against a really good basketball team, but again I felt all along that I've got a pretty good group here."
Thursday's 72-66 victory over No. 7 Michigan State was Nevada's first win in NCAA Tournament play. Prior to their victory over the Spartans, the Wolf Pack were 0-2 in NCAA Tournament play, losing first-round games in 1984 and 1985.
But Gonzaga could not stop the Wolf Pack (25-8), who controlled the game with a balanced attack, placing all five starters in double figures, led by Kevinn Pinkney with 20 points. Nevada stormed out to a 34-16 lead and led by as many as 20 points.
"We planned on attacking down low," said Nevada forward Nick Fazekas, who contributed 16 points and 10 rebounds. "Coach told us that they don't really want to play defense down there. They just want to count on going to the offensive end and doing their thing down there."
Todd Okeson added 19 points, including key back-to-back 3-pointers in the first half that helped Nevada (25-8) put Gonzaga in an early hole. The Wolf Pack had too many weapons as Kirk Snyder, the Western Athletic Conference Player of the Year, scored 18 points and Garry Hill-Thomas chipped in with 10.
Gonzaga (28-3) came out with more energy in the second half but got no closer than eight points as the Bulldogs could not get enough stops to put serious pressure on the Wolf Pack, who played with poise and confidence down the stretch.
Gonzaga guard Blake Stepp continued to struggle, shooting just 3-of-18 from the floor, including 1-of-12 from 3-point range. He was 2-of-11 in Gonzaga's first-round win over Valparaiso.
"Blake has probably faced that defense 31 times this year," Gonzaga coach Mark Few said. "Grab and hold and play him physical and get a lot of help. They (Nevada) are a very athletic team."
The Bulldogs also could not overcome center Ronny Turiaf's foul trouble. Turiaf picked up three fouls in the first half in four minutes, then went back to the bench after getting his fourth just two minutes into the second half.
"Turiaf was in foul trouble and didn't play most of the first half," Snyder said. "I think that was a big thing."
Gonzaga closed to 60-52 on Stepp's two free throws, but Okeson's 3-pointer slowed the Bulldogs' momentum.
Turiaf, who finished with 15 points and 13 rebounds, tried to take over the game down the stretch, but it was much too late.