KANSAS CITY, Missouri (Ticker) -- Joey Graham and Oklahoma State delivered an early knockout blow.
Graham scored 20 of his 21 points in the first half as the second-seeded Cowboys built a 22-point halftime lead and coasted to a 70-53 victory over Memphis in the second round of the East Rutherford Region.
The Cowboys (29-3) won for the 19th time in 20 games and advanced to play Pittsburgh on Thursday in New Jersey. Oklahoma State is in the "Sweet 16" for the first time since 2000.
"Coach (Eddie Sutton) told us that we've got to jump on these guys from the get-go and that's what we tried to go," Graham said. "The rim just felt like the ocean. I couldn't miss."
Oklahoma State jumped to a 13-point lead in the first eight minutes, building a 21-8 cushion on a dunk by Graham. Graham later hit a pair of 3-pointers in a 10-2 run that closed a first half in which the Cowboys shot a sizzling 68 percent (17-for-23).
"They manhandled us physically," Memphis coach John Calipari said. "Instead of coming together, we all tried to do it ourself. They lulled us into that and we had turnover after turnover."
The lead grew to as high as 27 when Ivan McFarlin scored on a layup with 13:57 left to make it 54-27. McFarlin had 13 points and 10 rebounds.
Memphis finally showed some life, going on a 11-0 run that included a 3-pointer by Antonio Burks. The Tigers cut it to 63-50 with 3:18 remaining on a free throw by Rodney Carney, but never recovered from the early barrage.
The lackluster second half left Sutton looking for more.
"I told them 'you're going to have to play 40 minutes from now on,'" Sutton said. "We didn't play as strong in the second half. We turned the ball over too much."
Five Cowboys scored in double figures with John Lucas adding 13, Tony Allen 11 and Daniel Bobik 10.
Burks scored 22 points for Memphis (22-8), which notched its first NCAA Tournament win since 1995 on Friday.
"I'm not holding my head down," Burks said. "I'm walking away proud."
The Tigers suffered their most lopsided loss of the season and finished with three defeats in four games.