MAUI (Ticker) -- Louisville has seen enough of Iowa in the early season.
Jeff Horner scored 10 of his 18 points during a decisive second-half run to lift the Hawkeyes to 76-71 upset of the 11th-ranked Cardinals in the opening round of the Maui Invitational.
Last year, Iowa beat Louisville, 70-69, in the season-opener on November 29, 2003.
Forward Juan Palacio's layup with 11:24 remaining gave Louisville its biggest lead, 48-42, before Horner answered with a 3-pointer six seconds later to spark Iowa's 25-8 run.
The Cardinals would not hit another basket over the next nine minutes, finishing 0-of-11 from the floor over that stretch and shooting just 27 percent (8-of-30) in the second half
After Louisville's Francisco Garcia hit a pair of free throws, Mike Henderson scored the next four points to reduce the Hawkeyes' deficit to 50-49. Horner followed with another 3-pointer to give Iowa the lead for good with 10:05 remaining.
Horner, who scored 10 points in the season opener against Western Illinois, hit two more jumpers during the run.
Greg Brunner scored five of his 13 during the burst and grabbed 10 rebounds in the contest for Iowa, which won the Maui Invitational in 1987.
Adam Haluska's jumper with 3:10 remaining capped the run and gave Iowa its largest lead, 67-56. Haluska, a transfer from Iowa State, scored 14 points and Pierre Pierce added 16 for the second straight game for the Hawkeyes, who will face Texas in the second round Tuesday.
Garcia scored 17 points and had three steals for Louisville, which shot 61 percent (14-of-23) in the first half en route to a 37-33 edge.
Ellis Myles added 12 points and eight rebounds and Otis George chipped in with 10 off the bench for the Cardinals.
Taquan Dean and Larry O'Bannon each scored 18 points in Louisville's season-opening victory at BYU Hawaii, but each guard was limited to just eight points in the loss.