HATTIESBURG, Mississippi (Ticker) -- Francisco Garcia and a pressure defense helped Louisville erase some recent struggles here.
Garcia scored 15 of his 25 points in the first half and Ellis Myles added 20 as No. 19 Louisville turned numerous turnovers into easy baskets in a 107-62 victory over Conference USA rival Southern Mississippi.
The Cardinals (13-3, 2-1 C-USA) had lost two of their last three games here before blowing open this one with 19 points off 12 first-half turnovers by the Golden Eagles.
"We weren't intending on pressing from the beginning," Louisville coach Rick Pitino said. "We went to it and tried to change up our presses, and we got some good runs. Our players were active from the start all the way to the final horn."
After the Golden Eagles made three of their first four shots for a 7-3 lead, the Cardinals went on a 19-1 run behind five points by Garcia. Louisville added a 17-5 spurt late in the opening half to take a 53-22 advantage with 3:35 remaining.
The Cardinals shot 69 percent (20-of-29) from the field and made 16-of-18 free throws in the opening 20 minutes en route to their fourth win in their last five meetings with Southern Miss (9-6, 0-3).
Garcia, who has surpassed 20 points in five of his last six games, was 7-of-9 from the floor and 3-of-3 from the arc. He handed out six assists and collected three steals.
"We stayed focused," Garcia said. "We've got to stay focused whether we've got a big lead at home or on the road. We talked about it in the locker room and we weren't going to let it happen today."
Larry O'Bannon, who also made all three of his 3-pointers, scored 16 points and Taquan Dean added 13 for Louisville, which sank 31-of-33 free throws and 10 3-pointers. The offensive efficiency helped Louisville to its largest margin of victory in the series between the schools.
The Cardinals lead the all-time series, 30-11.
Rashaad Carruth scored a career-high 25 points and grabbed eight rebounds but committed seven of Southern Miss' 23 turnovers.
"I have to go back to what wins games," Southern Miss coach Larry Eustachy said. "I think these guys who are supposedly great motivators are way overrated. I think we need self-motivators. There is no secret formula or trick. There is a cloud over this program which has been lingering for a long time and there's an attitude that what happened tonight was OK."