LOUISVILLE, Kentucky (Ticker) -- Memphis coach John Calipari's milestone win turned out to be surprisingly easy.
Darius Washington scored 25 points and Calipari picked up his 300th win as a college coach in an 85-68 victory over No.9 Louisville in a Conference USA matchup.
The lower ranked team had won seven of the last eight meetings in the series, and Memphis jumped all over Louisville in the first half in this one and never let up.
"It was our day today. We played hard, we scrambled and we played hard on defense, but it was our day," Calipari said. "We know they're a top-10 team, and we know how fortunate we were to come in and play that way."
The Tigers led, 34-22, at the half as the Cardinals shot 25 percent (5-of-20). Louisville entered the game as the conference leader in shooting at 48 percent but finished at 33 percent (19-of-58).
"Memphis deserves all the credit. They outplayed us at every position tonight," Louisville coach Rick Pitino said. "They are a very talented team, they are probably the most talented team that we faced this season."
Rodney Carney scored 24 points and Duane Erwin grabbed 10 rebounds for Memphis (14-10, 7-3 C-USA). The Tigers shot 51 percent (25-for-49) and outrebounded the Cardinals, 41-30.
Memphis entered the game 0-4 against ranked opponents, losing by an average of 16 points.
"We chose to play a ridiculous schedule and my ego got in the way," Calipari said. "With two freshmen starting, playing teams like Pittsburgh, Syracuse and Maryland was the dumbest thing we could have done."
Louisville (20-4, 8-2) entered the game with an eight-game conference winning streak, tied for longest in school history.
The 17-point loss was Louisville's worst home conference defeat since a 74-57 defeat to Alabama-Birmingham on February 21, 2001.
"If there's one thing I've learned in this business, it's that you enjoy winning," Calipari said. "The minute winning is a relief, you need to go home, stop coaching and retire. You must enjoy wins and I want my team to enjoy this win."