CHARLOTTE, North Carolina (Ticker) -- Curtis Withers refused to allow his team to look ahead to a possible first-place showdown with Louisville.
Withers scored 25 points and grabbed 11 rebounds as No. 21 Charlotte won its seventh straight contest with an 81-58 victory over Southern Mississippi in a Conference USA game.
The 49ers (21-4, 12-2 C-USA) have won the last 12 meetings against the Golden Eagles and maintained their first-place tie with Louisville for the top spot in the conference standings. The Cardinals defeated Memphis, 53-44, on Saturday and will host Charlotte on Thursday.
Withers, the conference's top scorer, is averaging more than 23 points over his last seven games. He scored 10 points in the first half to give the 49ers a 41-21 lead at intermission.
Charlotte held Southern Mississippi (10-17, 1-14) to 31 percent (9-of-29) shooting from the floor in the first half.
"Southern Miss really is undersized," Charlotte coach Bobby Lutz said. "They play tough. They're just not big enough. I thought we had an advantage. We certainly wanted to get it inside to (Withers)."
Withers scored 15 points in the second half and combined with E.J. Drayton to score the first 14 points after halftime, which gave Charlotte a 55-34 lead.
"The ball was thrown to me a little more tonight and I took advantage of it," Withers said.
Eddie Basden, the Conference USA Player of the Week in two of the past three weeks, scored 17 points and Drayton added 14 for the 49ers, who have won 10 straight at home.
Basden and Brendan Plavich were among the seniors playing in their final home game at Halton Arena.
"I've had a wonderful career here with a tremendous amount of support from the fans and students," Basden said. "It was an honor to play here."
"I don't know if I want to play without him," Lutz said. "He's handled himself so well on and off the court. I'm really proud of him."
Rashaad Carruth scored 22 points and Mildon Ambres had 14 for the Golden Eagles, who have lost nine in a row and 15 of their last 16.