| Rank | Team | Player | Projection | Opponent |
| 1 |  | Kurt Warner | 300 pass yards, 2 pass TD, 2 INT | at |  |
| 2 |  | Kyle Orton | 255 pass yards, 3 pass TD | vs |  |
| 3 |  | Matt Schaub | 265 pass yards, 3 pass TD, 1 INT | at |  |
| 4 |  | Donovan McNabb | 240 pass yards, 2 pass TD, 20 rush yards | at |  |
| 5 |  | Jay Cutler | 250 pass yards, 2 pass TD | vs |  |
| 6 |  | Peyton Manning | 250 pass yards, 2 pass TD, 1 INT | vs |  |
| 7 |  | Trent Edwards | 245 pass yards, 2 pass TD, 1 INT | vs |  |
| 8 |  | David Garrard | 255 pass yards, 1 pass TD | at |  |
| 9 |  | Aaron Rodgers | 240 pass yards, 2 pass TD, 1 INT | at |  |
| 10 |  | Brett Favre | 235 pass yards, 2 pass TD, 1 INT | at |  |
| 11 |  | Gus Frerotte | 265 pass yards, 1 pass TD, 2 INT | vs |  |
| 12 |  | Marc Bulger | 225 pass yards, 1 pass TD, 1 INT | vs |  |
| 13 |  | Dan Orlovsky | 230 pass yards, 1 pass TD, 2 INT | at |  |
| 14 |  | Chad Pennington | 220 pass yards, 1 pass TD, 1 INT | at |  |
| 15 |  | Eli Manning | 200 pass yards, 1 pass TD | vs |  |
| 16 |  | Matt Ryan | 210 pass yards, 1 pass TD, 1 INT | at |  |
| 17 |  | Ben Roethlisberger | 205 pass yards, 1 pass TD, 1 INT | at |  |
| 18 |  | Derek Anderson | 205 pass yards, 1 pass TD, 2 INT | vs |  |
| 19 |  | Jeff Garcia | 195 pass yards, 1 pass TD, 1 INT | at |  |
| 20 |  | Tyler Thigpen | 205 pass yards, 1 pass TD, 2 INT | vs |  |
| 21 |  | Jason Campbell | 190 pass yards, 1 pass TD, 1 INT | vs |  |
| 22 |  | Matt Cassel | 190 pass yards, 1 pass TD, 1 INT | at |  |
| 23 |  | Joe Flacco | 185 pass yards, 1 INT | at |  |
| 24 |  | JaMarcus Russell | 160 pass yards, 1 pass TD, 1 INT | vs |  |
| 25 |  | Ryan Fitzpatrick | 165 pass yards, 1 pass TD, 2 INT | vs |  |
| 26 |  | Kerry Collins | 150 pass yards, 0 pass TD, 1 INT | vs |  |
| 27 |  | Seneca Wallace | 140 pass yards, 1 pass TD, 2 INT | vs |  |
| 28 |  | Brad Johnson | 130 pass yards, 2 INT | at |  |
.
