Edwards has weapons at his disposal in Terrell Owens and Lee Evans, both of whom gained more than 1,000 yards last year. But with Lynch missing the game due to suspension, the offense will struggle. Look for Edwards to throw with limited success. If you have another option, this is the week to go with it.
Owens' presence in the lineup will assure Evans sees fewer double-teams than in the past. With the Patriots running out to a quick lead, Evans should get his receptions and is a viable WR option in deep leagues.
Two years after breaking the season-single scoring record, Moss will get off to a hot start against a poor Bills defense. Expect some big plays from New England's passing game including a couple TDs from Moss.
Welker is Brady's security blanket so he will get plenty of touches. While Moss may get the bigger numbers, Welker will be a big asset in leagues with points for receptions and is a must-start for your squad.
After trading Richard Seymour, the Patriots defense looks vulnerable. Fortunately for New England fans, the Bills aren't much of a test, especially without Marshawn Lynch. Look for Buffalo to attack the Patriots' new cornerbacks but with little success.