Garrard fell apart last year, in large part because the Jaguars' offensive line was decimated. Garrard is healthy and ready to go, but he doesn't have a lot of playmakers around him. He should do OK against a divisional rival he knows well, even if he doesn't get back to 2007 form.
With Fred Taylor gone, Jones-Drew is the focal point of the Jags' offense. He hasn't proven he can be an every-down back, but he says he's ready to take on the challenge. The diminutive Jones-Drew is nursing a sore shin, but his coach expects him to play. Rashad Jennings and Chauncey Washington will get a shot if Jones-Drew isn't able to play.
The question is, will Holt be more of a coach on the field, or the same kind of game-breaker he was in St. Louis? He's actually only 33, which is younger than other productive receivers. But there's no way Holt will put up St. Louis-like numbers with this quarterback and offensive line.
The former first-round pick of the Vikings showed some flashes of brilliance in the preseason. He had 147 receiving yards in one game and gives Jacksonville a deep threat it hasn't had. But he hasn't proved he can do it consistently at any point of his NFL career. Still, expect him to make at least one flashy play against Indy.
Lewis makes some plays that make you think he's going to be a star, but he makes some mistakes as well. Lewis had a nice game against Indy last December (6 catches, 55 yards), and will be able to contribute on Sunday.
The Jags' defense took a step back last year. They may return to form, but not here against Peyton Manning. Manning appears to be fired up and won't give Jacksonville many opportunities to make defensive plays.
Manning threw for 364 yards last December against Jacksonville and should continue his success here. Manning made a point of playing more in the preseason to get his rhythm going early and establish chemistry with his new receivers. Everything looked pretty good and he should be ready to go.
Addai is back in a two-back system, and is no longer a top-10 fantasy back in most people's minds. He looked good in flashes in the preseason. But the Jags have had success slowing the Colts' running game in the past, so don't expect a huge outburst in Week 1.
The 5-foot-10, 210-pound back should make an immediate impact. Rookies can contribute at running back right off the bat and many people think Brown is better than Addai. Keep a close eye on Brown stealing red-zone carries.
With Marvin Harrison gone, Gonzalez is poised to be a go-to guy who produces steadily throughout the season. He was a bit inconsistent last year, but you should expect him to show up every week in 2009.
Two years ago, Jags quarterback David Garrard was one of the best at avoiding turnovers. That wasn't the case last year. Which Garrard will it be this year? Expect the Colts to generate enough pass rush to get at least two turnovers.