| Rank | Team | Player | Projection | Opponent |
| 1 |  | Peyton Manning | 320 pass yards, 3 pass TD | vs |  |
| 2 |  | Philip Rivers | 285 pass yards, 2 pass TD | at |  |
| 3 |  | Matt Schaub | 275 pass yards, 1 pass TD, 1 INT | at |  |
| 4 |  | Donovan McNabb | 225 pass yards, 3 pass TD, 1 INT | vs |  |
| 5 |  | Drew Brees | 215 pass yards, 3 pass TD, 1 INT | vs |  |
| 6 |  | Ben Roethlisberger | 230 pass yards, 2 pass TD, 1 INT | at |  |
| 7 |  | Tom Brady | 225 pass yards, 2 pass TD, 1 INT | vs |  |
| 8 |  | Joe Flacco | 210 pass yards, 2 pass TD | at |  |
| 9 |  | Kurt Warner | 225 pass yards, 2 pass TD, 2 INT | at |  |
| 10 |  | Aaron Rodgers | 200 pass yards, 2 pass TD | at |  |
| 11 |  | Tony Romo | 205 pass yards, 2 pass TD, 1 INT | at |  |
| 12 |  | Matt Hasselbeck | 180 pass yards, 3 pass TD, 1 INT | vs |  |
| 13 |  | Jay Cutler | 210 pass yards, 1 pass TD, 1 INT | vs |  |
| 14 |  | Kyle Orton | 200 pass yards, 1 pass TD | vs |  |
| 15 |  | Vince Young | 155 pass yards, 40 rush yards, 1 rush TD, 1 INT | at |  |
| 16 |  | Eli Manning | 210 pass yards, 1 pass TD, 2 INT | vs |  |
| 17 |  | Matt Ryan | 200 pass yards, 1 pass TD, 1 INT | vs |  |
| 18 |  | Alex Smith | 190 pass yards, 1 pass TD | vs |  |
| 19 |  | Carson Palmer | 195 pass yards, 1 pass TD, 1 INT | vs |  |
| 20 |  | David Garrard | 180 pass yards, 1 pass TD, 1 INT | vs |  |
| 21 |  | Jason Campbell | 165 pass yards, 2 pass TD, 2 INT | at |  |
| 22 |  | Josh Freeman | 155 pass yards, 1 pass TD, 1 INT | vs |  |
| 23 |  | Matthew Stafford | 175 pass yards, 2 INT | at |  |
| 24 |  | Matt Cassel | 130 pass yards, 1 pass TD | at |  |
| 25 |  | Chad Henne | 135 pass yards, 1 pass TD, 1 INT | at |  |
| 26 |  | Jake Delhomme | 130 pass yards, 1 pass TD, 2 INT | at |  |