| Rank | Team | Player | Projection | Opponent |
| 1 |  | Peyton Manning | 350+ pass yards, 3 pass TD | at |  |
| 2 |  | Kurt Warner | 300 pass yards, 3 pass TD, 1 INT | at |  |
| 3 |  | Brett Favre | 285 pass yards, 3 pass TD | vs |  |
| 4 |  | Donovan McNabb | 280 pass yards, 2 pass TD | at |  |
| 5 |  | Ben Roethlisberger | 240 pass yards, 3 pass TD, 1 INT | at |  |
| 6 |  | Tony Romo | 260 pass yards, 2 pass TD, 1 INT | vs |  |
| 7 |  | Philip Rivers | 240 pass yards, 2 pass TD | at |  |
| 8 |  | Matt Schaub | 235 pass yards, 3 pass TD, 2 INT | vs |  |
| 9 |  | Drew Brees | 225 pass yards, 2 pass TD, 1 INT | at |  |
| 10 |  | Matt Hasselbeck | 220 pass yards, 2 pass TD, 2 INT | at |  |
| 11 |  | Tom Brady | 205 pass yards, 2 pass TD, 1 INT | vs |  |
| 12 |  | Aaron Rodgers | 205 pass yards, 2 pass TD, 1 INT | vs |  |
| 13 |  | Vince Young | 155 pass yards, 1 pass TD, 30 rush yards, 1 rush TD | at |  |
| 14 |  | Josh Freeman | 135 pass yards, 1 pass TD, 45 rush yards, 1 rush TD, 1 INT | vs |  |
| 15 |  | Matthew Stafford | 210 pass yards, 1 pass TD, 1 INT | vs |  |
| 16 |  | Carson Palmer | 175 pass yards, 2 pass TD | at |  |
| 17 |  | Eli Manning | 190 pass yards, 1 pass TD | vs |  |
| 18 |  | Kyle Orton | 190 pass yards, 1 pass TD | vs |  |
| 19 |  | Jay Cutler | 195 pass yards, 1 pass TD, 1 INT | vs |  |
| 20 |  | Alex Smith | 200 pass yards, 1 pass TD, 2 INT | at |  |
| 21 |  | Matt Cassel | 185 pass yards, 1 pass TD, 1 INT | vs |  |
| 22 |  | Marc Bulger | 180 pass yards, 1 pass TD, 1 INT | vs |  |
| 23 |  | Joe Flacco | 165 pass yards, 1 pass TD, 1 INT | vs |  |
| 24 |  | David Garrard | 165 pass yards, 1 pass TD, 1 INT | vs |  |
| 25 |  | Mark Sanchez | 175 pass yards, 1 pass TD, 2 INT | at |  |
| 26 |  | Jake Delhomme | 150 pass yards, 1 pass TD | vs |  |
| 27 |  | Jason Campbell | 150 pass yards, 1 pass TD, 1 INT | at |  |
| 28 |  | Matt Ryan | 150 pass yards, 1 pass TD, 2 INT | at |  |
| 29 |  | Trent Edwards | 145 pass yards, 1 pass TD, 2 INT | at |  |
| 30 |  | Chad Henne | 125 pass yards, 1 pass TD, 1 INT | at |  |
| 31 |  | Brady Quinn | 85 pass yards, 1 INT | at |  |
| 32 |  | Bruce Gradkowski | 90 pass yards, 2 INT | vs |  |
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