| Rank | Team | Player | Projection | Opponent | |
| 1 | ![]() | Tony Romo | 310 pass yards, 2 pass TD, 5 rush yards, 1 INT Romo has thrown for more than 280 yards in each of his three games this season, and the Cowboys got back on track a bit in their last game against Houston. Expect another strong outing from Romo this week. | vs | ![]() |
| 2 | ![]() | Drew Brees | 265 pass yards, 3 pass TD Arizona's defense was picked apart by Philip Rivers last week and Brees should be able to do the same. Expect a big week. | at | ![]() |
| 3 | ![]() | Aaron Rodgers | 255 pass yards, 3 pass TD, 10 rush yards Rodgers has recorded multiple touchdowns in every game this season. He has a good chance to continue that streak against a Redskins pass defense ranked 31st in the league. | at | ![]() |
| 4 | ![]() | Peyton Manning | 280 pass yards, 2 pass TD Manning has thrown 11 touchdown passes on the year with just one interception. There are few more consistent fantasy starters in the league. That shouldn't change this week against the Chiefs. | vs | ![]() |
| 5 | ![]() | Matt Ryan | 235 pass yards, 2 pass TD Ryan's numbers have been solid this season, though just outside of the fantasy elite. The Browns' secondary just gave up 371 yards passing to Cincinnati, so look for a good game out of Ryan. | at | ![]() |
| 6 | ![]() | Eli Manning | 235 pass yards, 2 pass TD, 1 INT Manning has not thrown a touchdown pass the past two weeks, but he faces a Houston team that has struggled against the pass. Manning should get back on track. | at | ![]() |
| 7 | ![]() | Matt Schaub | 235 pass yards, 2 pass TD, 1 INT Schaub could be under a lot of pressure from a Giants defense that recorded 10 sacks last week. A strong week could depend on Andre Johnson's availability, so monitor Johnson's status this week if are deciding between Schaub and another option. | vs | ![]() |
| 8 | ![]() | Carson Palmer | 210 pass yards, 2 pass TD, 1 INT Palmer has been inconsistent this season, though he's riding high off a 371-yard, two touchdown performance against the Browns. The Bucs have one of the league's best pass defenses and have not faced an offense with as many weapons as Cincinnati. | vs | ![]() |
| 9 | ![]() | Philip Rivers | 215 pass yards, 1 pass TD Rivers has not exactly destroyred the Raiders -- he has a 9:6 TD:INT ratio in eight career games -- so don't expect more than average production this week. | at | ![]() |
| 10 | ![]() | Kevin Kolb | 210 pass yards, 2 pass TD, 2 INT Michael Vick's injury makes it likely that Kolb will start against the 49ers this week. San Francisco is ranked 20th in the league in pass defense, so this could be the week Kolb gets back on track after a shaky start. | at | ![]() |
| 11 | ![]() | Kyle Orton | 230 pass yards, 1 pass TD, 2 INT Orton reached 50 passing attempts for the second straight week against the Titans and will likely continue to approach that number as long as Denver's running game remains anemic. Expect the Ravens to force Orton to throw this week again. | at | ![]() |
| 12 | ![]() | Sam Bradford | 185 pass yards, 2 pass TD, 5 rush yards, 1 INT Bradford has looked sharp and smart, especially for an NFL rookie. He runs a very efficient offense that should continue to put up decent numbers. At least enough to make Bradford a solid backup in most fantasy leagues. | at | ![]() |
| 13 | ![]() | Alex Smith | 200 pass yards, 2 pass TD, 2 INT Smith has thrown only three touchdowns this season compared to seven interceptions. Don't expect much from him against an Eagles team that is ranked fifth in pass defense. | vs | ![]() |
| 14 | ![]() | Matt Cassel | 185 pass yards, 1 pass TD, 10 rush yards, 1 INT Before his three-touchdown performance against the 49ers, Cassel was downright ugly in his first two starts. He may have to be on top of his game coming off the bye week if the Colts get out to a lead quickly and force Kansas City to throw. | at | ![]() |
| 15 | ![]() | Joe Flacco | 185 pass yards, 1 pass TD, 1 INT Flacco looked poised last week against a tough pass rush. It was a significant improvement over his disastrous start against the Bengals in Week 2. If Ray Rice and Willis McGahee are both limited this week, Flacco will have to air it out. | vs | ![]() |
| 16 | ![]() | David Garrard | 165 pass yards, 1 pass TD, 20 rush yards, 1 INT Garrard turned in a steady performance last week, easing some of the concerns about his starting position. Still, 163 yards passing yards make it difficult to justify a spot on most fantasy rosters, especially if that's considered a good day. | at | ![]() |
| 17 | ![]() | Donovan McNabb | 180 pass yards, 1 pass TD, 1 INT In five career games against Green Bay, McNabb has accounted for 12 touchdowns and racked up more than 1,350 yards. Those numbers -- and the fact Shaun Hill threw for 300 yards against Green Bay last week -- make him a nice start. | vs | ![]() |
| 18 | ![]() | Vince Young | 170 pass yards, 1 pass TD, 10 rush yards, 1 INT Young is playing well but he is not putting up much in terms of fantasy production. He is a decent QB2 option this week. | at | ![]() |
| 19 | ![]() | Derek Anderson | 180 pass yards, 1 pass TD, 2 INT Anderson was repalced by Max Hall during last week's game against the Chargers. A starter for Week 5 has not been named, but avoid using Anderson this week regardless of who gets the nod. | vs | ![]() |
| 20 | ![]() | Jay Cutler | 165 pass yards, 1 pass TD, 5 rush yards, 1 INT Cutler was knocked out with a mild concussion after taking nine sacks in the first half against the Giants. If he can play, he'll be facing some of the pressure-heavy schems he faced last week, though the Panthers are not the Giants. If Cutler can't go, Todd Collins or Caleb Hanie provide little value. | at | ![]() |
| 21 | ![]() | Shaun Hill | 175 pass yards, 1 pass TD, 2 INT Matt Stafford could return from his shoulder injury this week. If not, Hill has proven a more than capable fill-in. Whoever starts will likely throw the ball a lot with the Lions perpetually playing from behind. | vs | ![]() |
| 22 | ![]() | Mark Sanchez | 160 pass yards, 1 pass TD, 5 rush yards, 1 INT Sanchez's early performance has made him a fringe starter in standard leagues, but it may be best to use a more reliable option this week considering the Vikings' pass defense is eighth in the league against the pass. | vs | ![]() |
| 23 | ![]() | Brett Favre | 175 pass yards, 2 INT The bye week may have allowed Favre and the Vikings to work out some of their offensive issues and add a huge weapon with Randy Moss, but the already stout Jets defense gets Darrelle Revis back this week. | at | ![]() |
| 24 | ![]() | Bruce Gradkowski | 155 pass yards, 1 pass TD, 2 INT Gradkowski has put up decent fantasy numbers since taking over, but he faces a tough Chargers defense in Week 5. He is not more than a QB2 this week. | vs | ![]() |
| 25 | ![]() | Josh Freeman | 120 pass yards, 1 pass TD, 15 rush yards, 2 INT Freeman was a steady performer through the first three weeks of the season though hardly dominant from a fantasy standpoint. He'll be available to start this week against the Bengals, though there are likely better options available. | at | ![]() |
| 26 | ![]() | Ryan Fitzpatrick | 140 pass yards, 1 INT Fitzpatrick threw two touchdowns to zero interceptions last week, but a paltry 128 yards won't send fantasy players running to the waiver wires. He's the quarterback of a bad run-first offense. Enough said. | vs | ![]() |
| 27 | ![]() | Seneca Wallace | 120 pass yards, 15 rush yards, 1 INT Jake Delhomme (ankle) was available to play last week as the team's third quarterback, so a return looks possible this week. However, Seneca Wallace will probably keep the reins after beating the Bengals last week. | vs | ![]() |
| 28 | ![]() | Jimmy Clausen | 130 pass yards, 0 pass TD, 2 INT Last week was a step forward for Clausen. He threw one touchdown to zero interceptions and completed better than 50 percent of his passes. He is still far from a viable fantasy option, however. | vs | ![]() |