| Pos. | Player | Projection |
| QB | Kyle Orton | 175 pass yards, 2 pass TD, 1 INT Orton's passing yardage has fallen in recent weeks, but he has thrown two touchdown passes in four of his seven starts this season and faces a team that has given up 11 passing touchdowns this season. Orton remains a viable option in all formats. |
| RB | Knowshon Moreno | 3 rec, 15 rec yards, 60 rush yards, 1 rush TD Moreno received all the carries in the Denver backfield last week and has scored in three of his four games this season. The 49ers have done a good job stopping the run in recent weeks, but Moreno should see enough touches to be productive this week. |
| WR | Brandon Lloyd | 5 rec, 80 yards, 1 TD Lloyd was held to just one catch last week, but his body of work still makes him a useful option in all fantasy formats. |
| WR | Jabar Gaffney | 5 rec, 50 yards Gaffney has recorded at least four catches and 50 yards in his last five games, so he is a good option in PPR leagues. However, his lack of touchdowns means he is not a great play this week in standard leagues. |
| WR | Eddie Royal | 3 rec, 30 yards Royal has not done much in recent weeks with the Broncos passing attack being held in check. Use a hotter option this week if available. |
| TE | Daniel Graham | 1 rec, 5 yards Graham has zero catches in his last two games, so he is not a viable fantasy option at this time. |
| K | Matt Prater | 2 PATs, 2 FGs The Broncos could wind up in a high-scoring game this week, so Prater is a good option even though he totaled just two points a week ago. |
| Defense | 2 sacks, 2 INT, 2 Fumbles Denver's defense has not been productive enough to be a fantasy factor at this point, but the 49ers are starting Troy Smith at QB, so it's not the worst play. | |
| Pos. | Player | Projection |
| QB | Troy Smith | 110 pass yards, 20 rush yards, 2 INT Smith takes over for the injured Alex Smith. You'd have to be very desperate to take a chance on him. |
| RB | Frank Gore | 3 rec, 30 rec yards, 90 rush yards, 1 rush TD The Broncos are 30th in the league in rush defense and have given up 12 touchdowns on the ground, so expect another big game from Gore this week. |
| WR | Michael Crabtree | 3 rec, 35 yards Crabtree did not do much last week, and he will have a tough time doing much in Week 8 against Champ Bailey. Look for an option with a better matchup. |
| WR | Josh Morgan | 2 rec, 15 yards Morgan continues to catch a couple passes a game, but he is not doing enough to be a fantasy factor at this point. |
| TE | Vernon Davis | 3 rec, 30 yards Davis stretched his touchdown streak to four games last week. He will remain a weekly option regardless of who starts at quarterback for the 49ers. |
| K | Joe Nedney | 1 PAT, 1 FG Nedney has been only average, but he could see a few opportunities this week. |
| Defense | 3 sacks, 1 INT The 49ers defense has played better the last couple weeks, but go with a defense with a better body of work this week if possible. | |