| Pos. | Player | Projection |
| QB | Matt Schaub | 205 pass yards, 2 pass TD Schaub has four touchdown passes and five interceptions in his past three games against the Colts, but this could turn into a shootout very quickly. |
| RB | Arian Foster | 2 rec, 15 rec yards, 110 rush yards, 1 rush TD The Colts have not been good against the run, and Foster ran over them for 231 yards in Week 1. He is a strong option in Week 8. |
| WR | Andre Johnson | 5 rec, 100 yards, 1 TD Johnson was able to rest his sore ankle over the Texans' bye week, so he should feel much better when he gets back on the field. |
| WR | Kevin Walter | 3 rec, 30 yards Walter was held without a catch in the Texans' last game and has not scored since Week 3. Use a different option. |
| WR | Jacoby Jones | 3 rec, 45 yards Jones should be completely healthy after the Texans' bye week. |
| TE | Owen Daniels | 2 rec, 30 yards, 1 TD Daniels has picked up the pace in recent weeks. |
| K | Neil Rackers | 3 PATs, 2 FGs Rackers scored 10 points against the Colts in Week 1, so he is a decent option this week in what figures to be a high-scoring game. |
| Defense | 1 sack, 1 INT Houston's defense has not been very productive, so avoid using them even though the Colts offense is pretty banged up. | |
| Pos. | Player | Projection |
| QB | Peyton Manning | 300 pass yards, 3 pass TD Manning has thrown 40 touchdown passes in 17 career games against the Texans, as Houston enters Week 8 as the worst pass defense in the league. Expect a big performance despite a depleted receiving corps. |
| RB | Joseph Addai | 50 rush yards Addai's status for Week 8 remains undecided. Addai has averaged a touchdown per game against the Texans in his career, so do not be afraid to use him if he suits up. |
| RB | Mike Hart | 15 rush yards Hart could be the team's primary back this week if both Joseph Addai (shoulder) and Donald Brown (hamstring) sit out. Hart will be a decent option in most leagues if he winds up with the starting role. |
| RB | Donald Brown | 2 rec, 10 rec yards, 10 rush yards Brown had time to heal during the Colts' bye week, but he remains questionable for Week 8. Monitor both his and Joseph Addai's status this week if Brown is part of your fantasy team. |
| WR | Reggie Wayne | 6 rec, 110 yards, 2 TD Wayne has not scored a touchdown since Week 2, but he is third in the league in receiving and has scored nine touchdowns in 17 career games against the Texans. Make sure he is in your lineup this week. |
| WR | Pierre Garcon | 4 rec, 65 yards, 1 TD Garcon had a big performance in the Colts' last game, and he should continue to be the second option in the passing game going forward due to injuries to Dallas Clark and Austin Collie. |
| TE | Jacob Tamme | 3 rec, 35 yards Tamme will take over as the starting tight end in the wake of Dallas Clark's season-ending wrist injury. Tamme has some potential in the Colts' offense, but stick with a safer option this week. |
| K | Adam Vinatieri | 4 PATs, 1 FG The Colts should be able to move the ball against the Texans, so Vinatieri should have a few opportunities for points. |
| Defense | 3 sacks The Colts' defense has forced just nine turnovers this season and faces a well rounded Houston offense in Week 8, so use a different defense. | |