| Pos. | Player | Projection |
| QB | Kerry Collins | 130 pass yards, 1 pass TD, 1 INT Collins had a nice game in Week 7, and he could get another start this week with Vince Young's status uncertain. However, Collins is not a great option this week against a Chargers pass defense that is giving up fewer than 160 passing yards per game. |
| RB | Chris Johnson | 2 rec, 20 rec yards, 80 rush yards, 1 rush TD Johnson will be a weekly starter for as long as he stays healthy, but he has a tough matchup this week against a Chargers' defense that has given up the fewest yards per game in the league. |
| WR | Kenny Britt | 5 rec, 70 yards, 1 TD Britt has been one of the hottest receivers in the league, so get him in your lineup even though he is facing a very good Chargers defense in Week 8. |
| WR | Nate Washington | 2 rec, 20 yards Washington has caught just one pass in each of the last three games and has a tough matchup, so avoid using him this week. |
| TE | Bo Scaife | 3 rec, 20 yards Scaife has been inconsistent this season and does not have a favorable matchup. |
| K | Rob Bironas | 2 PATs, 2 FGs Bironas has been the top kicker in standard fantasy formats, so keep using him even though the Titans might find points hard to come by this week. |
| Defense | 4 sacks, 1 INT Tennessee's defense is leading the league in sacks and turnovers, so start them even against a Chargers team that is leading the league in total offense. | |
| Pos. | Player | Projection |
| QB | Philip Rivers | 225 pass yards, 1 pass TD, 1 INT Rivers put up good numbers last week despite being without both his starting wide receivers, so expect him to have a strong week against the Titans' 23rd-ranked pass defense regardless of the players that will catch his passes. |
| RB | Ryan Mathews | 1 rec, 5 rec yards, 55 rush yards Mathews had a disappointing performance a week ago, but he remains the top option in the San Diego backfield. Mathews does not have a great matchup this week, but he should see enough work to warrant a start in most formats. |
| RB | Mike Tolbert | 1 rec, 10 rec yards, 20 rush yards Tolbert has scored in four straight games, but he has received just five total carries over the last two weeks. Go with a player that is seeing more touches. |
| RB | Darren Sproles | 4 rec, 35 rec yards, 5 rush yards Sproles has seen increased work in the passing game the last couple weeks, so he could provide some sneaky production this week if Ryan Mathews is unable to get going in the running game again. |
| WR | Patrick Crayton | 7 rec, 80 yards Crayton has played a big role in the passing game the last couple weeks and should again be a starter in Week 8. Philip Rivers is leading the league in passing, so Crayton is a strong Week 8 play in most formats. |
| WR | Buster Davis | 5 rec, 40 yards Davis will have some value in deeper formats if Legedu Naanee sits out again, so consider adding him if you are looking for a wide receiver. |
| WR | Legedu Naanee | 1 rec, 5 yards Naanee could return this week, but he was not doing enough prior to the injury to warrant a start even if he does suit up. |
| TE | Antonio Gates | 4 rec, 50 yards, 1 TD Gates had another productive game a week ago despite battling a toe injury, so keep him in your lineup as long as he is active. |
| K | Nate Kaeding | 1 PAT, 1 FG Kaeding is questionable for this week, so be prepared to use a different option. Teammate Kris Brown is a viable fill-in. |
| Defense | 3 sacks, 1 INT The Chargers are tied with the Titans for the most sacks and have given up the fewest yards per game. They are a strong weekly option at this point. | |