| Pos. | Player | Projection |
| QB | Kyle Orton | 250 pass yards, 1 pass TD, 10 rush yards Orton is coming off his best game of the season, but he has a tough matchup this week on the road against a Chargers defense that is ranked second in the league. |
| RB | Knowshon Moreno | 2 rec, 35 rec yards, 45 rush yards, 1 rush TD Moreno put up huge numbers last week, but he will have a tough time being as productive against a strong Chargers defense. |
| RB | Lance Ball | 5 rush yards Ball was the Broncos' backup running back last week, but he will not see enough carries to be a fantasy factor. |
| WR | Brandon Lloyd | 4 rec, 100 yards, 1 TD Lloyd has put up two huge games in a row and still leads the league in receiving. Expect him to remain very active in the passing game. |
| WR | Jabar Gaffney | 4 rec, 70 yards Gaffney has recored at least 50 yards in seven straight games, so he is worth a start this week if you are looking for a consistent, safe option. |
| WR | Demaryius Thomas | 1 rec, 20 yards Thomas has not done enough in recent weeks to warrant a start against a Chargers defense that is third in the league against the pass. |
| TE | Daniel Graham | 1 rec, 10 yards Graham was held without a catch once again last week. He is not a viable fantasy option at this point. |
| K | Matt Prater | 2 PATs, 1 FG Prater has averaged just over five points in his last five games, and he is unlikely to do much this week with the Broncos facing a strong Chargers defense. Go with another kicker. |
| Defense | 2 sacks, 1 INT Denver's defense has not done enough to warrant a start this week against the league's top offense. | |
| Pos. | Player | Projection |
| QB | Philip Rivers | 270 pass yards, 3 pass TD Rivers has accounted for 15 total touchdowns in nine career games against the Broncos and is red hot, so expect another strong showing from him. |
| RB | Ryan Mathews | 1 rec, 10 rec yards, 40 rush yards The Broncos are 30th in run defense and have given up a league-high 14 scores on the ground, so get Mathews back in your lineup following last week's bye. |
| RB | Mike Tolbert | 1 rec, 10 rec yards, 30 rush yards, 1 rush TD The Broncos are not very good against the run and have given up a lot of rushing touchdowns, so Tolbert could be a nice flex option in deeper leagues this week. |
| WR | Patrick Crayton | 4 rec, 80 yards, 1 TD Crayton has put up decent numbers over the last few weeks, but he may be back in a reserve role in Week 11. Have other options ready. |
| WR | Seyi Ajirotutu | 3 rec, 65 yards, 1 TD Floyd should return to the field this week after missing the last three games. Since the Chargers do not play until Monday, carefully monitor Floyd's status this week if you are considering using him. |
| WR | Malcom Floyd | 1 rec, 5 yards Floyd should return to the field this week after missing the last three games. Since the Chargers do not play until Monday, carefully monitor Floyd's status this week if you are considering using him. |
| TE | Antonio Gates | 4 rec, 50 yards, 1 TD Gates had a week to rest with the Chargers off last week, but he is still not 100 percent. Gates is a bit of a risk this week since he will likely be a game-time decision and the Chargers do not play until Monday. |
| K | Nate Kaeding | 4 PATs, 1 FG Kaeding should be back in action this week after missing three games. He will be a good option in what figures to be a high-scoring game. |
| Defense | 3 sacks, 1 INT San Diego's defense is still ranked second in the league, but they have forced just 12 turnovers and have a tough matchup this week against a potent Broncos offense. Look for a better matchup. | |
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