| Pos. | Player | Projection |
| QB | ![]() |
Ryan Fitzpatrick250 pass yards, 2 pass TDs, 2 INTs
Fitzpatrick was stymied by the Niners' defense in Week 5, as they held him to 126 passing yards, no touchdowns and one interception. The Cardinals have allowed just five passing touchdowns this season, making Fitzpatrick an iffy fantasy start once again. |
| RB | ![]() |
Fred Jackson55 rush yards, rush TD, 3 rec, 25 rec yards
For the second straight week, Jackson rushed for just 29 yards to go with one catch. Jackson is still trying to get back on track after his knee injury. Fantasy owners should give him one more chance in Week 6 at Arizona before benching him. |
| RB | ![]() |
C.J. Spiller40 rush yards, 3 rec, 30 rec yards
Spiller carried the ball seven times for 24 yards in the Bills' Week 5 loss at San Francisco. Spiller (shoulder) and Fred Jackson (knee) are both coming back from injuries. Arizona isn't as tough of a foe, but Spiller is better as a flex than an RB2 this week. |
| WR | ![]() |
Stevie Johnson6 rec, 65 yards, rec TD
After scoring in his first three games of the season, Johnson was held out of the end zone for the second consecutive game in Week 5 at San Francisco. He caught six passes for 39 yards. Week 6's opponent, the Cardinals, have allowed just five touchdown passes all season. |
| WR | ![]() |
Donald Jones4 rec, 35 yards
Jones followed up a breakout Week 4 with a two-catch, 13-yard disappointment in Week 5 at San Francisco. He's not worth owning in most formats, and the Cardinals have a tough pass defense. |
| TE | ![]() |
Scott Chandler5 rec, 45 yards, rec TD
Chandler led the Bills with 40 receiving yards in Week 5 at San Francisco. He caught four passes for the third time this season and he remains Ryan Fitzpatrick's second-favorite target behind Stevie Johnson. |
| K | ![]() |
Rian Lindell3 PATs, FG
Lindell kicked just his second field goal of the season in Week 5 at San Francisco. Fantasy owners should continue to steer clear of Lindell, as the scoring opportunities just aren't there for him. |
| DEFENSE |
INT, 3 Sacks
The Bills have recorded three forced turnovers and one sack over the past two games against the Patriots and 49ers. Now they travel to Arizona, where Kevin Kolb has been inconsistent and the Cardinals' running game has been decimated by injuries. Consider starting this unit on the road in Week 6. |
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| Pos. | Player | Projection |
| QB | ![]() |
Kevin Kolb240 pass yards, 2 pass TDs, INT
Kolb was held without a touchdown against the Rams in Week 5, one week after throwing three touchdown passes against the Dolphins. He has shown some flashes, but this offense is too inconsistent (it gave up nine sacks to St. Louis) to trust him. |
| RB | ![]() |
LaRod Stephens-Howling55 rush yards, 4 rec, 40 rec yards
Stephens-Howling (hip) missed the past two games, but with Beanie Wells (toe) and Ryan Williams (shoulder) also injured and out, the team needs Stephens-Howling to come back and assume his third-down back role. Consider other options for Week 6 against Buffalo, though. |
| RB | ![]() |
William Powell30 rush yards, 1 rec, 15 rec yards
The Cardinals' running backs are really beat up, with Beanie Wells, Ryan Williams and LaRod Stephens-Howling each nursing injuries. Powell could see more action in Week 6 against Buffalo, but that doesn't make him a suggested fantasy player. |
| WR | ![]() |
Larry Fitzgerald7 rec, 80 yards, rec TD
While No. 11 didn't score in Week 5, he did catch 8-of-15 targets for 92 yards at St. Louis. A good week may lie ahead, as the Bills rank among the bottom-third in pass defenses and have allowed nine passing touchdowns so far. |
| WR | ![]() |
Andre Roberts4 rec, 55 yards, rec TD
After scoring two touchdowns in Week 4, Roberts returned to earth with five catches for 39 yards and no scores in Week 5. The Bills are a below-average pass defense, though, which makes Roberts an intriguing bye-week replacement. |
| TE | ![]() |
Rob Housler3 rec, 40 yards
Housler had his most active game in Week 5 at the Rams, with six targets, but he still caught only three passes for 45 yards. He's like Scott Chandler without all of those pesky touchdowns. |
| K | ![]() |
Jay Feely2 PATs, 2 FGs
Feely finally missed his first field goal of the season in Week 5, but even so, he's not getting a lot of scoring chances this season (just nine field goal attempts so far). |
| DEFENSE |
2 INTs, 4 Sacks
The Cardinals' defense was held to just one sack and one forced turnover at St. Louis in Week 5, which was down from its average over the previous weeks. The Bills have a pretty good offense these days, which makes the Cards a mediocre option in Week 6. |
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