With E.J. Manuel at the helm for the Bills, the Patriots defense has a huge day. If they're available in your league, they make a great stream option.
Miami's defense was under the radar last season, but that won't be the case in 2013, especially after it gets off to a huge start against Brandon Weeden and the Browns.
Houston has one of the best defenses in the league and a great matchup against the Chargers. They'll be the top performing defense this week.
The Buccaneers revamped secondary should improve the league's 32nd-ranked pass defense from a year ago. I love their matchup against the Jets this week.
They may not be the Steelers of old, but they should still be able to take advantage of an offense helmed by Jake Locker.
Detroit may have one of the best defensive lines in the league. They'll give up their fair share of points, and they'll need to play smarter, but they could create some real havoc in the backfield this year.
Brian Urlacher and Lovie Smith may be gone, but the Bears' defensive identity will remain intact. They'll force three turnovers and get to Andy Dalton four times in their Week 1 win.
In certian weeks, the Vikings will look like a nice play. After suffering losses in their secondary, though, you won't want to run them out there against the Lions.
The Chiefs could develop into a fantasy mainstay, but those of you who like to ride the defense carousel may want to consider them this week. It doesn't get much better than a matchup with the Jaguars.
They get overlooked because they're in a division with the 49ers and Seahawks, but the Cardinals have a strong, playmaking defense, as well. They'll show that in a win over the Rams Sunday.
Even without Von Miller, the Broncos defense will get off to a good start in 2013. Of course, it'll help when Peyton Manning and the offense hand it a 14-0 lead.
The division-rival 49ers get more attention, but the Seahawks have the best defense in the league. It'll show up Week 1 against the Panthers.
Like the Cardinals, the Rams get overlooked by virtue of being in the same division as two of the best defenses in the league. They'll get after Carson Palmer and create a couple turnovers this Sunday.
The Redskins need Brian Orakpo and Ryan Kerrigan to get after the quarterback if they are to improve on defense this year. Michael Vick's potential for turnovers makes the Redskins a fringe starting option this week.
The Raiders very well might be the worst team in the league this season. You'll be able to take advantage of this defense all year long.
If there were ever a week to stream the Colts defense, it's this one. It could have a big day against what could be the worst offense in the league.
The Jets defense may not be the reason this team has become a laughingstock, but they won't do much of anything special against the Buccaneers this week.
It might be hard to belive it now, but the Bengals and Bears will go down as two of the best teams in 2013. The Bengals defense is too good not to get after Jay Cutler, even in a loss.
The Browns may not be realistic playoff contenders, but it won't be the fault of the defense. This is a strong unit all around that would be worthy of playing in January.
Don't let their performance Week 1 color how you feel about this defense the rest of the season. This could be a very strong unit. Seattle is just a tough draw the first week of the year.
We'll get our first real look at Monte Kiffin's new look Cowboys defense, including DeMarcus Ware as a down lineman. The Giants aren't the greatest matchup in the world, but the Cowboys will likely rate as a starting defense this week.
The Titans may prove to be the type of defense you could stream with the right matchup, but that isn't the case this week. You shouldn't be considering it at all.
The Packers are definitely a fantasy option, but this isn't the greatest matchup in the world. I do see them being able to force a few turnovers, though.
No matter what happens against Green Bay, the 49ers will have one of the best defenses in the league this year. If you own them, you're starting them every week, regardless of matchup.
We've grown accustomed to shootouts between the Falcons and Saints, and this week will be no different. Of course, that makes it hard to start either defense.
The Saints gave up the most fantasy points to quarterbacks, running backs and wide recievers last year. Yeah, they're still pretty bad.
You can't start the Eagles as your defense Week 1. There are just too many unknowns to trust it just yet.
Terrible defense, terrible matchup. Do not even think about starting the Chargers.
This ain't your older sibling's Ravens defense, and it will show Week 1. The Broncos will make a lot of defenses look bad this year, but this trend will continue for the Ravens all season.
It's looking like another long year in Buffalo. Drawing the Patriots Week 1 won't help.
It's hard to imagine fantasy owners wanting to start the Jacksonville defense at any point this season. You certainly don't want to start them this week.
The Giants defense really disappointed last year, and they suffered a few key injuries during the preseason. They may prove a good fantasy play, but you don't want to start them against the Cowboys.