The Seahawks completely shut down Newton, holding him to 125 passing yards, one touchdown and 38 rushing yards. The Bills will have no such luck.
Williams had a nice showing against a strong defense, running for 76 yards on 16 carries (4.8 YPC) and catching three passes for 14 yards. He'll take advantage of a much weaker defense in Buffalo.
DeAngelo Williams dominated the work out of the backfield, and ended up with a very impressive showing against the Seahawks. Tolbert's nothing but a depth guy.
Fantasy owners continue to underrate Smith at their own peril. On a day when the Panthers passing game couldn't get much going, he caught six passes for 51 yards and a touchdown. He's in for a bigger day Sunday.
Ginn caught the only ball thrown his way, good enough for 10 yards, and while the Panthers struggled to get anything going through the air, Ginn simply isn't a viable fantasy option.
LaFell didn't show up in the box score last week, though he was targeted on two incomplete passes that were negated by penalties. He should not be owned.
Olsen led the Panthers with 10 targets and caught five passes for 56 yards. He'll find the end zone for the first time this season on Sunday.
It was a boring Week 1 for Gano, as one extra point was the lone kick he attempted against the Seahawks. He'll be a bit more active this week.
Despite the loss, the Panthers defense was one of the most impressive units last week, led by star-in-the-making Luke Kuechly. They definitely warrant regular starting consideration for the rest of the season.
Manuel enjoyed a nice NFL debut, throwing for 150 yards and two touchdowns and running for an additional 23 yards. The Panthers present a much tougher challenge and will give him a bit of a wake-up call.
Spiller ran for just 41 yards on 17 carries, and his five receptions went for just 14 yards. It was troubling for his owners to see Fred Jackson rack up 107 total yards, but Spiller will give them a useful day this week.
C.J. Spiller was a first-round pick, but Jackson had the better Week 1, racking up 107 total yards. He may be able to carve out a decent fantasy role.
Johnson had six targets last week, catching three of them for 39 yards and one touchdown. It doesn't get easier for him against the Panthers, but he'll find a way to give his owners a productive day.
Graham had all of one target last week. He's not on the fantasy radar.
Chandler caught four of the six passes thrown his way for 38 yards last week. He cannot be trusted as a starter with all the superior options at tight end.
Carpenter didn't have any field goal attempts against the Patriots, but against a stout Carolina defense, I'm betting that changes this week.
The Bills held their own against New England, forcing three turnovers and sacking Tom Brady twice. A full-strength Panthers unit will present a tough matchup, making the Bills unworthy of fantasy consideration.