The onus will be on Andrew Luck to keep this offense going with Reggie Wayne out for the season. The Texans have allowed the fourth-fewest fantasy points per game to quarterbacks.
Richardson has been a disaster since moving over to Indianapolis. Houston presents a decent matchup, as the Texans have allowed 17.8 fantasy points per game to opposing running backs.
Hilton's owners are the big winners in the fallout from Reggie Wayne's injury. He shoud see a ton of targets the rest of the year.
Heyward-Bey is worth adding with Reggie Wayne out for the year, but he should be on your bench this week.
Fleener could play a bigger role in the offense with Reggie Wayne out for the year. It will be interesting to see how many targets he gets on Sunday.
If the Colts offense struggles without Reggie Wayne, Vinatieri's owners could benefit.
Case Keenum played well in his first career start two weeks ago. The Colts should not be considered a stream option this week unless the Texans start a running back other than Arian Foster or Ben Tate.
Keenum played well in his first career start two weeks ago, throwing for 271 yards and a touchdown against the Chiefs. He could be a QB2 this week.
Foster had to leave Houston's last game because of a hamstring injury. The Texans say he will be a gametime decision for the Sunday nighter.
Johnson's owners had to breathe a sigh of relief when Case Keenum played well in his first career start. Start him as usual this week.
The Colts have allowed the 14th most fantasy points per game to receivers this season. The bet here is that Andre Johnson can better take advantage.
Graham still holds down the starting job in Houston, but you should be able to do better at the position.
Bullock has quite simply been bad this year, going just 12-for-17 on field goals and not making one from beyond 50 yards.
Even without Reggie Wayne, the Colts present some challenges for the Texans. Stay away.