LOUISVILLE, Kentucky (Ticker) -- Florida State's first overtime game resulted in an historic loss.
Henry Miller's 25-yard touchdown run in the extra session gave Louisville its biggest upset ever, a 26-20 triumph over the fourth-ranked Seminoles.
Louisville (3-2) entered the year with high hopes and a Heisman Trophy candidate in quarterback Dave Ragone but fell flat on its face in a season-opening loss to Kentucky. Meanwhile, Florida State (4-1) was looking for its fifth straight win overall and 13th straight in the series.
Seminoles quarterback Chris Rix had a shaky outing in a game played during a huge rainstorm. His most crucial mistake came on the first play of overtime, when he was picked off by free safety Anthony Floyd.
It was Floyd's 18th career interception.
Needing only a field goal to win, Louisville handed the ball to Miller on its first play and the senior burst through the middle and scored easily for the victory. It was the Cardinals' first victory against a team ranked in the top five.
"I don't know what to say," Louisville coach John L. Smith said. "Our kids hung in there, they believed in themselves."
Ragone completed 15-of-27 passes for 182 yards and two touchdowns, including a one-yard scoring toss to Damien Dorsey early in the fourth quarter that forged a 20-20 tie. Ragone had declared before the game that this was the Cardinals' "Super Bowl."
"They've got a quarterback and that quarterback is as good as anybody I've seen," Seminoles coach Bobby Bowden said.
With Rix struggling, Florida State's running game never got fully untracked despite 59 yards on seven carries by Nick Maddox. Tailback Greg Jones managed just 32 yards on 13 carries as he was held well below 100 yards for the second straight game.
Ragone struggled to complete 2-of-8 passes in the first half as Louisville trailed 13-6. The Cardinals turned in a sloppy effort as they were penalized eight times for 100 yards and had just 77 yards of total offense. Louisville twice had 1st-and-goal inside the Seminoles 5 and managed just three points.
"We played well in the first half," Smith said. "We just made some mistakes that kept us out of the end zone."
Louisville's young offensive line struggled to protect its quarterback but Ragone demonstrated his toughness and scrambling ability by registering 43 yards on 21 carries
Ragone, who was sacked six times, was the Cardinals' leading rusher before Miller's touchdown gave him 55 yards on 11 carries.
Ragone finally got going and engineered a seven-play, 51-yard drive to tie the game early in the third quarter on a 30-yard touchdown pass to Joshua Tinch. Tinch had four catches for 93 yards.
Rix responded with his best series of the night as he was 5-of-5 on a drive that resulted in a 21-yard TD toss to Talman Gardner for a 20-13 lead. Gardner, who also had a 23-yard TD catch in the first half, was Rix's favorite target with eight receptions for 130 yards.
That was the last solid drive that Rix put together as Florida State's offense stalled in the fourth quarter. Rix was 14-of-33 for 173 yards and was sacked three times.
Florida State defensive end Alonzo Jackson did most of the damage on Ragone as he had five sacks that resulted in losses of 30 yards.