PITTSBURGH (Ticker) -- Pittsburgh remained perfect against the Mid-American Conference as Rod Rutherford passed for a career-high 316 yards and three touchdowns in a 37-19 victory over Toledo.
The Panthers (4-1) improved to 19-0 all-time against the MAC, including 2-0 this season. Pittsburgh opened the year with a 27-14 victory over Ohio.
Toledo (3-2) opened the scoring on Brian Jones' 44-yard TD pass to Carl Ford less than two minutes into the second quarter, but the Panthers erupted for three touchdowns in just over 10 minutes to open a 21-6 halftime lead.
Rutherford, who completed 18-of-27 passes and also ran for a score, gave Pittsburgh the lead for good with an 18-yard TD pass to Lamar Slade with 10:21 left in the half.
After Raymond Kirkley scored on a one-yard run, Rutherford tossed the first of his two TD passes to freshman Larry Fitzgerald, a seven-yarder with just 13 seconds left before intermission.
Pittsburgh, which has won 10 of its last 11 games, made it 27-6 on Rutherford's eight-yard TD scamper with 2:37 remaining in the third quarter.
Fitgerald hauled in a 26-yard TD in the fourth quarter and finished with six receptions for a season-high 121 yards.
Forced to play catchup, Toledo's Brian Jones completed 31-of-45 passes for 306 yards with two touchdowns and two interceptions. The Rockets were held to 104 yards rushing.