NORMAN, Oklahoma (Ticker) -- On a raw and rainy day, second-ranked Oklahoma dealt Seneca Wallace and No. 13 Iowa State a cold dose of reality.
Wallace met his match in the physical Sooners, who blew out the Cyclones early and coasted to a 49-3 Big 12 Conference victory.
There was no letdown for Oklahoma (7-0, 3-0 Big 12 South) after last week's 35-24 victory over Texas. The Sooners set the tone early and never eased up.
It took Oklahoma just 62 seconds to get on the board as Terrence Simms recovered a blocked punt in the end zone for a touchdown on the game's opening possession.
"Our game plan every week is try and dominate up front," Oklahoma defensive tackle Kory Klein said. "We wanted to make them one-dimensional. We were fortunate to stop the run and make them pass to beat us."
Iowa State (6-2, 3-1 Big 12 North) had been off to its best start since 1938. However, the Cyclones went three-and-out on their first four possessions and were outgained, 206-4, in the first half.
Wallace likely saw his Heisman Trophy hopes washed away following a nightmare performance. He completed 1-of-12 passes for zero yards in the first two periods and finished just 4-of-22 for 43 yards and three interceptions.
"It was an incredible defensive game against a tremendous player," Oklahoma coach Bob Stoops said. "We still believe Seneca Wallace is a guy who deserves all the Heisman attention he has gotten."
As the rain intensified, the Sooners continued to pour it on, with Quentin Griffin and Kejuan Jones each rushing for a pair of TDS in the opening 30 minutes.
"It was really tough to bounce back and get into a rhythm after the way the first half went," Wallace said. "Our game was just to have offense, period."
The 5-7 Griffin surpassed the century mark for the ninth time in his career, rushing for 111 yards on 23 carries. Jones added 86 yards on 25 attempts.
"Quentin is just making people miss," Oklahoma offensive tackle Jamaal Brown said. "Once he gets off the line of scrimmage, he makes people miss and gets 10 or 15 yards that he shouldn't get."
Oklahoma continued its dominance of Iowa State in one of the nation's most lopsided rivalries, increasing its lead in the all-time series to 64-5-2.
The Cyclones dropped to 0-49-2 against top-five opponents.
This is hardly how Iowa State envisioned beginning a brutal stretch. The Cyclones visit Texas next week, then have road contests at Kansas State and Colorado in November.
"Their defense was about the best I've coached against and I've around for a long time," Iowa State coach Dan McCarney said. "I don't believe I've ever played against a defense as good as that one. They dominated our offense from beginning to end."
Nothing went right for Iowa State. The lone highlight in the first half came when Mark Clayton recovered a fumbled punt at the Oklahoma 1-yard line with just under four minutes left. But the Sooners kept Iowa State out of the end zone and took over on downs.
Iowa State got its only points on Adam Benike's 29-yard field goal in the third quarter.
"From the way we played this year, I didn't think we'd get beat like this," Iowa State wide receiver Lane Danielson said. "They were very tough."
Oklahoma dominated every aspect of the contest. The Sooners picked up 25 first downs to just five for the Cyclones and held a 367-60 edge in total yardage. Iowa State was 0-for-12 on third-down conversions, while Oklahoma was 10-of-21.
Oklahoma's Nate Hybl tossed a 22-yard TD pass to Brandon Jones later in the third period before Renaldo Works' 11-yard TD run capped an eight-minute drive for the Sooners in the fourth quarter.
Hybl made no spectacular plays but completed 14-of-24 passes for 168 yards in an efficient performance. Griffin scored on runs of 15 and four yards to give the Sooners a 21-0 lead early in the second quarter before interceptions set up Oklahoma's final two scores of the first half.
Brandon Everage led Oklahoma's dominant defense with two interceptions, a sack and a forced fumble. His first interception set up a 13-play, 72-yard drive that Jones capped with a one-yard plunge.
On Iowa State's ensuing posession, defensive back Derrick Strait intercepted a deflected pass and returned it to the Iowa State 20. The Sooners needed only four plays to make it 35-0 on Jones' second one-yard TD run.
Michael Wagner led the Cyclones with just 21 yards on five carries.