PALO ALTO, California (Ticker) -- Carson Palmer and Southern California settled another score.
Palmer continued his late push into the Heisman Trophy race by throwing four touchdown passes as ninth-ranked USC coasted to a 49-17 Pac-10 Conference victory over Stanford.
The Trojans (7-2, 5-1 Pac-10) had lost four straight games to Oregon before racing past the Ducks two weeks ago at Autzen Stadium. After a bye week, USC made amends Saturday against the Cardinal, who had defeated the Trojans three straight times by a combined 11 points.
The most frustrating of those losses came last season when Chris Lewis threw a game-winning 20-yard TD pass on the final play of the game.
USC prevented any chance of some late-game heroics by scoring 14 points in both the third and fourth quarters to turn the game into a rout.
Palmer completed 22-of-32 passes for 317 yards and was not intercepted. In his last three games, Palmer has thrown for 1,113 yards and 13 touchdowns. He has 61 career touchdown passes, breaking the school mark of 58 held by Rob Johnson.
"This is really something to watch," USC coach Pete Carroll said of Palmer. "He's really bringing it together and capitalizing on his past experiences. He's in control of the game, and it's not difficult for him right now."
Keary Colbert caught TD passes of 17 yards in the first quarter and 13 yards in the third for USC.
The other TD passes for Palmer came on an eight-yarder to Mike Williams in the first quarter and a 22-yarder to Alex Holmes in the third that gave the Trojans a 35-10 lead.
The touchdown to Holmes followed an interception by defensive end Kenechi Udeze.
Williams caught eight passes for 94 yards and has 58 catches this season, breaking the Pac-10 freshman record of 55 set by Washington's Reggie Williams last year.
USC never has lost four straight games to Stanford in a series that dates to 1905. The Trojans hold a 54-24-3 record against their oldest rival.
Stanford (2-7, 1-5) has lost six of its last seven games.
"They made some big plays and we didn't respond in the second half the way we would have liked," Stanford coach Buddy Teevens said. "I didn't see it as us backing off as much as them making plays and us not."
Kyle Matter started in place of the injured Lewis on Saturday and threw touchdown passes of six yards to Ryan Wells in the first quarter and 11 yards to Teyo Johnson in the fourth.
Matter completed 23-of-35 passes for 165 yards.
With Palmer passing at will, the Trojans had little need for the ground game. Justin Fargas had a team-high 43 yards on nine carries and scored on a seven-yard run in the second quarter.
The Trojans also scored on touchdown runs of four yards by Malaefou MacKenzie and six yards by Sultan McCullough in the fourth quarter.