CHESTNUT HILL, Massachusetts (Ticker) -- Derrick Knight rushed for a career-high 171 yards and two touchdowns as Boston College pulled away from Syracuse, 41-20, to become bowl eligible.
Brian St. Pierre threw for 284 yards and one touchdown, a seven-yard toss to Sean Ryan with 2:22 remaining in the third quarter that snapped a 20-20 tie.
After Brandon Brokaw's one-yard TD run with 10:02 left, Knight capped the scoring with a career-long 70-yard burst with 3:40 to play.
Ryan set career bests with six catches for 105 yards for the Eagles (6-4, 1-4 Big East), who won their first conference game and snapped the Orangemen's three-game winning streak.
Syracuse's Walter Reyes rushed for 95 yards and one score, an eight-yard run that tied the game at 20 with 6:25 to play in the third quarter.
Troy Nunes completed just 14-of-34 passes for 131 yards, one touchdown and one interception for the Orangemen (4-7, 2-4), whose slim bowls hopes ended.
The loss ended Syracuse's string of 15 consecutive winning seasons and saddled the Orangemen with their first losing campaign since 1986.
Syracuse, which allowed Boston College to gain 511 yards, concludes its season against No. 1 Miami on November 30.