WACO, Texas (Ticker) -- Quentin Griffin rushed for 152 yards and scored four touchdowns as sixth-ranked Oklahoma recovered from its first loss of the season with a 49-9 Big 12 Conference rout of Baylor.
Griffin had TD runs of 25 and one yard in the third quarter as Oklahoma (9-1, 5-1 Big 12 South) built a 42-3 cushion. The senior running back also had a one-yard scoring run in the first quarter and 35-yard TD reception in the second.
Derrick Strait took care of the defense, halting a first-half scoring drive with an interception and returning another 77 yards for a score in the fourth quarter.
Nate Hybl passed for 181 yards and two TDS, helping the Sooners bounce back from a 30-26 loss to Texas A&M, which dropped them from first to fourth in the all-important Bowl Championship Series standings.
Oklahoma clinches a berth in the Big 12 title game with a win over Texas Tech next week.
Rashad Armstrong had 103 yards rushing for Baylor (3-8, 1-6 South), which suffered its sixth straight loss. The Bears have been blown out in consecutive weeks by top-five teams, falling to Texas, 41-0, last saturday.
The Sooners improved to 12-0 in the all-time series. Baylor coach Kevin Steele, who was fired earlier this season but decided to close the year, finished 0-4 against the Big 12 powerhouse.
Oklahoma had the ball for only 22 1/2 minutes but scored on seven of its 11 possessions while totaling 401 yards. Baylor had a string of eight drives where it punted six times and had two passes intercepted.
Griffin asserted himself early. After a 42-yard punt return by Antonio Perkins, Griffin touched the ball five times on a six-play, 43-yard TD drive, capping it with a one-yard run 6:09 into the game.
Baylor answered with a field goal and forced a punt, but Oklahoma turned it on in the second quarter, scoring a pair of touchdowns for a 21-3 lead.
The Sooners went 71 yards in five plays for their first TD of the period, Griffin's 35-yard reception. They then went 66 yards in 14 plays as Kejuan Jones found the end zone from 14 yards with 2:51 left in the half.
Oklahoma got the ball first in the second half and needed only three plays from scrimmage to score as Hybl threw a 40-yard TD pass to Antwone Savage.
The Sooners scored three touchdowns in as many third-quarter drives. Griffin capped a 58-yard march with a 25-yard run and a 66-yard drive with a one-yard plunge, making it 42-3.
That was it for Griffin, who jumped two spots to third in school history with 4,236 all-purpose yards. He also has 374 touches since his last fumble.
Baylor quarterbacks Aaron Karas and Greg Cicero combined to go 21-of-38 for 241 yards with a pair of interceptions, the only two turnovers of the game. The Bears began the day second-to-last in the nation with a minus-17 turnover margin.
Armstrong picked up his first career 100-yard game on 19 carries.