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EUGENE, Oregon (Ticker) -- Oregon may think Cody Pickett and Washington are overrated, but he and Reggie Williams proved otherwise.

Pickett became the Pac-10 Conference's all-time leading passer and Williams had a school-record 14 catches and three touchdowns as Washington scored six unanswered touchdowns for a 42-14 victory over No. 22 Oregon.

Oregon safety Keith Lewis fueled one of the Pac-10's biggest rivalries when he called Pickett and the Huskies "overrated." Pickett threw for 316 yards and four touchdowns and has 3,818 career passing yards, breaking the previous record of Washington State's Ryan Leaf, who had 3,637.

Pickett tried to get Lewis's reaction to no avail.

"During the game, I asked him a question or two, but he didn't have much to say," Pickett said. "To come in and play with the crowd talking and the team talking made the win even sweeter."

Williams was Pickett's favorite target with 198 yards receiving and put away the game with a pair of exciting touchdown catches in the fourth quarter. On those receptions, Williams caught short passes over the middle before cutting to his right the first time and his left the second for a 47-yard TD and a 41-yard score.

"Reggie is a big-play player and we try to feature him in our offense," Washington coach Rick Neuheisel said. "We try to move him around so people have to find him. He and Cody have a great relationship."

The Ducks (7-4, 3-2 Pac-10) built a 14-0 lead in the first quarter on two touchdown passes by Jason Fife before the Huskies got on the board on a five-yard TD run by Rich Alexis. Pickett hit Williams for a 23-yard touchdown for a 14-14 tie at halftime.

Alexis added a touchdown run in the third that gave Washington (6-5, 3-4) the lead for good and Pickett found Patrick Reddick for a six-yard TD catch to make it 28-14.

Oregon suffered its third loss at home this season, disappointing an Autzen Stadium record crowd of 57,112 fans who braved cold, wet weather. It was the Ducks' home finale.

"Everyone who said we couldn't win on the road at Autzen was wrong," Williams said. "I'm just thankful we got the win today."

"I think the weather came and we didn't handle it very well," Oregon coach Mike Bellotti said. "We didn't handle the weather very well and when it's in our house we can't do that."

Fife struggled after the first quarter and completed just 10-of-29 passes for 170 yards. He was benched for to start the second half and backup Kellen Clemens was picked off by defensive back Derrick Johnson on his first pass to set up Alexis's second score.

"Coach Bellotti told me earlier in the week that it might happen but nobody likes to get pulled," Fife said. "I really don't care about personal stats as much as I care about the team. Everybody's just angry. Nobody wants to lose to the Huskies - nobody wants to lose a game."

Another turnover by Oregon led to Reddick's touchdown as Keenan Howry fumbled a punt. The Huskies' two scoring drives in the third quarter totaled just 30 yards.

Clemens threw three incompletions in addition to his interception.

"We wanted to change the tempo and get a little excitement going," Bellotti said. "Kellen made a couple of plays and missed a couple of plays. He looked like a youngster out there. But I also wanted to have Jason watch from the sidelines a little."

Alexis shouldered the workload on the ground by gaining 122 yards on 30 carries for Washington. The Huskies finished with 479 yards of total offense.

"The whole line gave us a great push today," Alexis said. "We came in, let it go and let it rip."

Oregon played without starting tailback Onterrio Smith, who was out with a sore right toe. Smith has 12 touchdowns and 1,101 yards rushing and missed what could be his home finale since the junior is contemplating entering the NFL draft.

The Huskies celebrated wildly on the field after the game, although few of the fans were left to witness it. Williams' first touchdown of the fourth quarter sparked a mass exodus among the Ducks' faithful.

"(The celebration) wasn't excessive," Huskies defensive tackle Terry Johnson said. "We earned this win and we had fun doing it. Once their tricks were out, it was a hard-nosed football game and all that mattered was who fought harder in the trenches."