Neither John nor Jim Harbaugh are hiding the fact the Thanksgiving Day contest between the Baltimore Ravens and San Francisco 49ers will be overshadowed by their historic matchup against each other.

They just hope everyone realizes each oversees a solid football team, too.

John's AFC North-leading Ravens host Jim's NFC West-leading 49ers on Thursday night in the first meeting between head-coaching brothers in NFL history.

John, who is in his fourth season coaching Baltimore, said the contest is going to be one to remember.

"It's an amazing thing. To say that you're not thinking about it probably wouldn't be real," John said. "It's a historic thing, it's very special. I couldn't be more proud for our parents or for Jim. I just think it's really neat."

Jim, in his first season with San Francisco (9-1), has remained more business-like leading up to the game. San Francisco can clinch the division with a win and a Seattle loss to Washington on Sunday.

"There's just not a lot of time to really even think about the warm and fuzzy reunions, or the nostalgia of it all," Jim said. "There's just work to be done."

The 49ers' surprising turnaround has been largely due to Harbaugh's tough attitude, and his players have followed suit. San Francisco hadn't won nine games in a season since going 10-6 in 2002 - the team's last playoff appearance.

John, meanwhile, has brought consistent winning back to Baltimore, leading the Ravens to at least the divisional round of the postseason in each of his previous three seasons.

Now, each have their teams in position for playoff runs.

"I'll tell you what, it's going to be a hard-fought game," John said. "I don't think it's going to be a trick 'em game.

"It's two very physical teams, two teams with quite a lot at stake. It's two teams that play a very similar style of football. It's going to be a great night for football. If you're a football fan I wouldn't think you'd want to miss this game."

Resurgent quarterback Alex Smith may get his toughest test of the season against Baltimore's fourth-ranked defensive unit, even if All-Pro linebacker Ray Lewis is held out for a second straight game.

Smith, after years of scrutiny, has thrived as a game manager under Jim Harbaugh, throwing 13 touchdown passes to four interceptions with a passer rating of 93.9 - seventh-best in the NFL.

He went 20 for 38 for 267 yards and two touchdowns in Sunday's 23-7 win over Arizona, hitting Michael Crabtree with seven passes for 120 yards.

Smith is confident the potential distraction of what is being dubbed as the "HarBowl" won't get in the way. It hasn't yet for his coach.

"No mention of his brother in regards to this game," Smith said. "It's business as usual, staying with our routine.

"It's a short week, we're traveling East, there will be obstacles for us that we have to overcome. It will be a crammed week."

John Harbaugh has kept mum on Lewis' status for Thursday, though the veteran said he's anxious to get back on the field after missing Sunday's 31-24 win over Cincinnati with a foot injury.

"I am taking every opportunity to get treatment on my foot to prepare to play on Thursday," Lewis said. "Anytime you see your team on the field, you always want to be out there with them. As the leader of your team, it doesn't sit well with me to be on the sidelines."

San Francisco tight end Vernon Davis said it will be a challenge facing the Ravens' tough defense with or without Lewis.

"It doesn't really make (any) difference whether he is playing or whether he isn't," Davis said. "I don't think that one guy on defense could make a big difference. It doesn't matter."

Baltimore may not agree with that sentiment. It gave up a season-high 483 total yards against the Bengals and allowed two rushing touchdowns for only the second time in 38 games dating back to 2009.

The Ravens may have their hands full again with running back Frank Gore , who needs 61 yards to pass late Hall of Famer Joe Perry (7,344) for the most in 49ers history.

Gore, who has been limited in practice due to a nagging right knee injury, ran for 88 yards on 24 carries Sunday. He bounced back after being held to zero yards on six carries Nov. 13 against the New York Giants after averaging 126.8 yards in five games prior to that performance.

The Baltimore offense may have to turn it up a notch, much like it did versus Cincinnati. The Ravens scored their most points since a 34-17 win over the New York Jets on Oct. 2, as Joe Flacco threw for 270 yards and two touchdowns. He hit rookie Torrey Smith with six passes for a season-high 165 yards, including a 38-yard TD in the fourth quarter.

Ray Rice , who ran for 104 yards and two touchdowns against the Bengals, will face a 49ers defense that leads the league against the run at 73.9 yards allowed per game.

The 49ers haven't allowed a 100-yard rusher since Nov. 22, 2009, a stretch of 35 consecutive games.

The most recent meeting was a defensive battle, with Baltimore winning 9-7 in San Francisco on Oct. 7, 2007.

Harbaughs move on after sharing Thanksgiving

BALTIMORE (AP) -- The Harbaugh brothers met in the middle of the field, hugged, expressed their love for each other and headed off in opposite directions.

After their much-anticipated, oft-analyzed and historic confrontation was over, John and Jim Harbaugh expressed gratitude over having the opportunity to face each other on Thanksgiving.

John was just little bit happier, of course, because his Baltimore Ravens beat Jim's San Francisco 49ers 16-6 Thursday night.

"I felt really humble, just thankful," John said. "Running across the field to my brother - he's my best friend, along with Mom and Dad and my wife. You don't put yourself in many other coaches' shoes, but you can put yourself in your brother's shoes. I'm really proud of him."

Although the 49ers (9-2) had their eight-game winning streak end, Jim Harbaugh was thankful for the experience of coaching against John in the first NFL game with two brothers on opposite sidelines as head coaches.

"I was proud to be part of it, proud to be part of the family," Jim said. "I was thankful on Thanksgiving. It was a wonderful thing."

Asked what he said to John, he replied, "I congratulated him and told him I loved him."

John, 49, and Jim, 47, grew up dueling each other in all sorts of games. This, however, was the first time their sibling rivalry was displayed on a national stage.

During the final minute, John got a Gatorade bath from his players - twice. After the game ended, the brothers hugged at midfield.

"There's a saying that says, `As iron sharpens iron, so does one man sharpen another,"' Jim said. "And I have to say my brother John is the sharpest iron I've ever encountered in my life."

The Ravens (8-3) sacked 49ers quarterback Alex Smith nine times, tying a franchise record, despite playing without middle linebacker Ray Lewis , the team's leading tackler and spiritual leader. Lewis was inactive for a second straight game with a foot injury.

Smith completed 15 of 24 passes for 140 yards and an interception, and San Francisco was held without a touchdown for the first time this season. Smith never could get into a rhythm against an aggressive defense that rarely let him set up in the pocket.

"It's tough to get ready for a defense like that in a short week. They do so many things," he said. "They're a great front. At home with the crowd noise, they were teeing off."

Terrell Suggs had three sacks for first-place Baltimore, which moved a half-game ahead of the Pittsburgh Steelers in the AFC North.

"That's always the game plan, to get after the quarterback, but I think the No. 1 game plan was to win the Harbaugh Bowl," Suggs said. "Coach tried to downplay it - act like it's not me against my brother, this is the Ravens vs. the 49ers and let's get win No. 8 and make sure our destiny is in our own hands - but it was really important to him. We as a team went out there and really wanted to win for him."

Now that it's over, the Harbaughs can put their rivalry on hold and get back to winning football games for reasons that involve division crowns and home-field advantage.

"For those two guys, they're probably glad it's over," Ravens center Matt Birk said. "They can breathe a sigh of relief, and now we can move on. Tonight just solidified that they're two great coaches with two pretty good football teams."

Baltimore broke a 6-6 tie with a 76-yard, 16-play drive that lasted more than 7 1/2 minutes and ended with an 8-yard touchdown pass from Joe Flacco to tight end Dennis Pitta with 14:56 left. Flacco went 4 for 4 for 34 yards and a touchdown on third down during the drive.

"When you have that kind of game plan - your line being so efficient on third downs - you have to come through," Flacco said.

Billy Cundiff wrapped up the scoring with his third field goal, a 39-yarder with 4:16 remaining.

In a game dominated by both defenses, Flacco finished 15 for 23 for 161 yards and Ray Rice ran for 59 yards on 21 carries.

The 49ers began the third quarter with a 13-play drive that lasted 7 1/2 minutes and produced a 52-yard field goal by David Akers for a 6-6 tie. The key play was an 18-yard completion from Smith to Michael Crabtree on a third-and-17 from the San Francisco 26.

The Ravens responded with their lone touchdown drive of the game.

Baltimore sacked Smith four times in the first half and picked off a pass in taking a 6-3 lead.

NOTES: Baltimore has won all six home games and 15 of 16. ... Gore finished with 39 yards on 14 carries. ... Although the Ravens had a first-and-goal at the 4 in second quarter, the 49ers held and kept intact their distinction of not allowing a rushing TD all season. ... Lee Evans had a catch for the Ravens, his first reception since Week 2 after missing seven games with an ankle injury.

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