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Updated: Thursday September 10, 3:43 AM
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| NFL Passing | AFC Passing | NFC Passing |
| Rank | Player | Team | G | Comp | Att | Att/G | Pct | Yds | Yds/G | Yds/Att | TD | Int | 1st | Sack | Rate |
| 1 | Drew Brees | NO | 16 | 413 | 635 | 39.7 | 65.0 | 5069 | 316.8 | 8.0 | 34 | 17 | 232 | 13 | 96.3 |
| 2 | Kurt Warner | ARI | 16 | 401 | 598 | 37.4 | 67.1 | 4583 | 286.4 | 7.7 | 30 | 14 | 220 | 26 | 96.9 |
| 3 | Jay Cutler | DEN | 16 | 384 | 616 | 38.5 | 62.3 | 4526 | 282.9 | 7.3 | 25 | 18 | 222 | 11 | 86.0 |
| 4 | Aaron Rodgers | GB | 16 | 341 | 536 | 33.5 | 63.6 | 4038 | 252.4 | 7.5 | 28 | 13 | 182 | 34 | 93.8 |
| 5 | Philip Rivers | SD | 16 | 312 | 478 | 29.9 | 65.3 | 4009 | 250.6 | 8.4 | 34 | 11 | 191 | 25 | 105.6 |
| 6 | Peyton Manning | IND | 16 | 371 | 555 | 34.7 | 66.8 | 4002 | 250.1 | 7.2 | 27 | 12 | 210 | 14 | 95.0 |
| 7 | Donovan McNabb | PHI | 16 | 345 | 571 | 35.7 | 60.4 | 3916 | 244.8 | 6.9 | 23 | 11 | 196 | 23 | 86.4 |
| 8 | Matt Cassel | NE | 16 | 327 | 516 | 32.3 | 63.4 | 3693 | 230.8 | 7.2 | 21 | 11 | 182 | 47 | 89.4 |
| 9 | Chad Pennington | MIA | 16 | 321 | 476 | 29.8 | 67.4 | 3653 | 228.3 | 7.7 | 19 | 7 | 180 | 24 | 97.4 |
| 10 | David Garrard | JAC | 16 | 335 | 535 | 33.4 | 62.6 | 3620 | 226.3 | 6.8 | 15 | 13 | 183 | 42 | 81.7 |
| 11 | Brett Favre | NYJ | 16 | 343 | 522 | 32.6 | 65.7 | 3472 | 217.0 | 6.7 | 22 | 22 | 184 | 30 | 81.0 |
| 12 | Tony Romo | DAL | 13 | 276 | 450 | 34.6 | 61.3 | 3448 | 265.2 | 7.7 | 26 | 14 | 150 | 20 | 91.4 |
| 13 | Matt Ryan | ATL | 16 | 265 | 434 | 27.1 | 61.1 | 3440 | 215.0 | 7.9 | 16 | 11 | 157 | 17 | 87.7 |
| 14 | Ben Roethlisberger | PIT | 16 | 281 | 469 | 29.3 | 59.9 | 3301 | 206.3 | 7.0 | 17 | 15 | 162 | 46 | 80.1 |
| 15 | Jake Delhomme | CAR | 16 | 246 | 414 | 25.9 | 59.4 | 3288 | 205.5 | 7.9 | 15 | 12 | 152 | 20 | 84.7 |
| 16 | Jason Campbell | WAS | 16 | 315 | 506 | 31.6 | 62.3 | 3245 | 202.8 | 6.4 | 13 | 6 | 162 | 38 | 84.3 |
| 17 | Eli Manning | NYG | 16 | 289 | 479 | 29.9 | 60.3 | 3238 | 202.4 | 6.8 | 21 | 10 | 169 | 27 | 86.5 |
| 18 | Matt Schaub | HOU | 11 | 251 | 380 | 34.5 | 66.1 | 3043 | 276.6 | 8.0 | 15 | 10 | 146 | 23 | 92.7 |
| 19 | Kyle Orton | CHI | 15 | 272 | 465 | 31.0 | 58.5 | 2972 | 198.1 | 6.4 | 18 | 12 | 141 | 27 | 79.6 |
| 20 | Joe Flacco | BAL | 16 | 257 | 428 | 26.8 | 60.0 | 2971 | 185.7 | 6.9 | 14 | 12 | 143 | 32 | 80.3 |
| 21 | Marc Bulger | STL | 15 | 251 | 440 | 29.3 | 57.0 | 2720 | 181.3 | 6.2 | 11 | 13 | 121 | 38 | 71.4 |
| 22 | Jeff Garcia | TB | 12 | 244 | 376 | 31.3 | 64.9 | 2712 | 226.0 | 7.2 | 12 | 6 | 125 | 23 | 90.2 |
| 23 | Trent Edwards | BUF | 14 | 245 | 374 | 26.7 | 65.5 | 2699 | 192.8 | 7.2 | 11 | 10 | 132 | 23 | 85.4 |
| 24 | Kerry Collins | TEN | 16 | 242 | 415 | 25.9 | 58.3 | 2676 | 167.3 | 6.4 | 12 | 7 | 133 | 8 | 80.2 |
| 25 | Tyler Thigpen | KC | 14 | 230 | 420 | 30.0 | 54.8 | 2608 | 186.3 | 6.2 | 18 | 12 | 127 | 26 | 76.0 |
| 26 | JaMarcus Russell | OAK | 15 | 198 | 368 | 24.5 | 53.8 | 2423 | 161.5 | 6.6 | 13 | 8 | 111 | 31 | 77.1 |
| 27 | Gus Frerotte | MIN | 11 | 178 | 301 | 27.4 | 59.1 | 2157 | 196.1 | 7.2 | 12 | 15 | 101 | 29 | 73.8 |
| 28 | Shaun Hill | SF | 9 | 181 | 288 | 32.0 | 62.8 | 2046 | 227.3 | 7.1 | 13 | 8 | 99 | 23 | 87.5 |
| 29 | Ryan Fitzpatrick | CIN | 12 | 221 | 372 | 28.6 | 59.4 | 1905 | 146.5 | 5.1 | 8 | 9 | 100 | 38 | 70.0 |
| 30 | Dan Orlovsky | DET | 10 | 143 | 255 | 25.5 | 56.1 | 1616 | 161.6 | 6.3 | 8 | 8 | 73 | 14 | 72.6 |
| 31 | Derek Anderson | CLE | 10 | 142 | 283 | 28.3 | 50.2 | 1615 | 161.5 | 5.7 | 9 | 8 | 82 | 14 | 66.5 |
| 32 | Seneca Wallace | SEA | 9 | 141 | 242 | 24.2 | 58.3 | 1532 | 153.2 | 6.3 | 11 | 3 | 72 | 14 | 87.0 |


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