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Updated: Monday May 20, 7:07 AM
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| NFL Defense | AFC Defense | NFC Defense |
| Rank | Player | Team | G | Tk | Ast | Sck | Stf | FF | FR | PD | Int | Yds | TD |
| 1 | Patrick Peterson | ARI | 16 | 52 | 3 | 0.0 | 1.0 | 0 | 5 | 17 | 7 | 64 | 0 |
| 2 | Frank Gore | SF | 16 | 0 | 0 | 0.0 | 0.0 | 0 | 4 | 0 | 0 | 0 | 0 |
| Robert Griffin III | WAS | 15 | 0 | 0 | 0.0 | 0.0 | 0 | 4 | 0 | 0 | 0 | 0 | |
| Kelvin Hayden | CHI | 16 | 24 | 11 | 0.0 | 0.0 | 0 | 4 | 5 | 1 | 39 | 0 | |
| Julius Peppers | CHI | 16 | 32 | 7 | 11.5 | 2.0 | 1 | 4 | 2 | 0 | 0 | 0 | |
| 6 | Brandon Banks | WAS | 12 | 0 | 0 | 0.0 | 0.0 | 0 | 3 | 0 | 0 | 0 | 0 |
| Sam Bradford | STL | 16 | 0 | 0 | 0.0 | 0.0 | 0 | 3 | 0 | 0 | 0 | 0 | |
| Randall Cobb | GB | 15 | 0 | 0 | 0.0 | 0.0 | 0 | 3 | 0 | 0 | 0 | 0 | |
| Luke Kuechly | CAR | 16 | 103 | 62 | 1.0 | 7.0 | 0 | 3 | 8 | 2 | 22 | 0 | |
| Stefan Logan | DET | 16 | 0 | 0 | 0.0 | 0.0 | 0 | 3 | 0 | 0 | 0 | 0 | |
| Cam Newton | CAR | 16 | 0 | 0 | 0.0 | 0.0 | 0 | 3 | 0 | 0 | 0 | 0 | |
| Carlos Rogers | SF | 16 | 50 | 6 | 1.0 | 0.5 | 0 | 3 | 7 | 1 | 63 | 1 | |
| Michael Vick | PHI | 10 | 0 | 0 | 0.0 | 0.0 | 0 | 3 | 0 | 0 | 0 | 0 | |
| Eric Weems | CHI | 16 | 0 | 0 | 0.0 | 0.0 | 0 | 3 | 0 | 0 | 0 | 0 | |
| Russell Wilson | SEA | 16 | 0 | 0 | 0.0 | 0.0 | 0 | 3 | 0 | 0 | 0 | 0 | |
| 16 | Michael Adams | ARI | 15 | 3 | 1 | 0.0 | 0.0 | 0 | 2 | 5 | 0 | 0 | 0 |
| Frank Alexander | CAR | 16 | 10 | 8 | 2.5 | 0.5 | 0 | 2 | 3 | 0 | 0 | 0 | |
| Christian Ballard | MIN | 16 | 9 | 6 | 1.0 | 1.0 | 0 | 2 | 0 | 0 | 0 | 0 | |
| Quincy Black | TB | 9 | 25 | 7 | 0.0 | 2.5 | 0 | 2 | 0 | 0 | 0 | 0 | |
| Michael Boley | NYG | 16 | 64 | 27 | 0.5 | 4.0 | 0 | 2 | 4 | 3 | 74 | 1 | |
| Zack Bowman | CHI | 11 | 2 | 0 | 0.0 | 0.0 | 0 | 2 | 2 | 0 | 0 | 1 | |
| Drew Brees | NO | 16 | 0 | 0 | 0.0 | 0.0 | 0 | 2 | 0 | 0 | 0 | 0 | |
| Stevie Brown | NYG | 16 | 56 | 10 | 0.0 | 2.0 | 2 | 2 | 11 | 8 | 307 | 0 | |
| Dez Bryant | DAL | 16 | 0 | 0 | 0.0 | 0.0 | 0 | 2 | 0 | 0 | 0 | 0 | |
| Rafael Bush | NO | 16 | 8 | 3 | 0.0 | 0.0 | 1 | 2 | 1 | 1 | 40 | 0 |
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