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Updated: Wednesday May 22, 7:08 AM
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| NFL Defense | AFC Defense | NFC Defense |
| Rank | Player | Team | G | Tk | Ast | Sck | Stf | FF | FR | PD | Int | Yds | TD |
| 1 | Aldon Smith | SF | 16 | 50 | 16 | 19.5 | 3.0 | 3 | 0 | 1 | 1 | 6 | 0 |
| 2 | Clay Matthews | GB | 12 | 32 | 11 | 13.0 | 5.0 | 1 | 0 | 2 | 0 | 0 | 0 |
| 3 | Charles Johnson | CAR | 16 | 31 | 12 | 12.5 | 1.0 | 7 | 1 | 4 | 0 | 0 | 0 |
| 4 | Jared Allen | MIN | 16 | 36 | 10 | 12.0 | 6.0 | 1 | 1 | 3 | 0 | 0 | 0 |
| 5 | Chris Clemons | SEA | 16 | 31 | 9 | 11.5 | 0.5 | 3 | 1 | 4 | 0 | 0 | 0 |
| Chris Long | STL | 16 | 25 | 8 | 11.5 | 4.0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Julius Peppers | CHI | 16 | 32 | 7 | 11.5 | 2.0 | 1 | 4 | 2 | 0 | 0 | 0 | |
| DeMarcus Ware | DAL | 16 | 33 | 23 | 11.5 | 4.5 | 5 | 1 | 0 | 0 | 0 | 0 | |
| 9 | Greg Hardy | CAR | 15 | 41 | 20 | 11.0 | 4.0 | 2 | 1 | 2 | 0 | 0 | 0 |
| Anthony Spencer | DAL | 14 | 55 | 40 | 11.0 | 6.5 | 2 | 1 | 3 | 0 | 0 | 0 | |
| 11 | Robert Quinn | STL | 16 | 24 | 5 | 10.5 | 2.0 | 1 | 0 | 2 | 0 | 0 | 0 |
| 12 | John Abraham | ATL | 16 | 32 | 4 | 10.0 | 5.0 | 6 | 0 | 7 | 0 | 0 | 0 |
| 13 | Cliff Avril | DET | 16 | 28 | 7 | 9.5 | 4.0 | 2 | 0 | 1 | 0 | 0 | 0 |
| 14 | Michael Bennett | TB | 16 | 34 | 7 | 9.0 | 10.0 | 3 | 0 | 2 | 0 | 0 | 0 |
| Daryl Washington | ARI | 16 | 108 | 26 | 9.0 | 6.5 | 2 | 1 | 4 | 1 | 7 | 0 | |
| 16 | Ryan Kerrigan | WAS | 16 | 42 | 12 | 8.5 | 3.0 | 2 | 1 | 8 | 1 | 28 | 1 |
| Brian Robison | MIN | 15 | 26 | 11 | 8.5 | 1.0 | 3 | 1 | 7 | 0 | 0 | 0 | |
| 18 | Everson Griffen | MIN | 16 | 20 | 3 | 8.0 | 1.5 | 0 | 2 | 2 | 1 | 29 | 1 |
| Bruce Irvin | SEA | 16 | 10 | 7 | 8.0 | 0.0 | 1 | 1 | 0 | 0 | 0 | 0 | |
| Cameron Jordan | NO | 16 | 40 | 26 | 8.0 | 4.5 | 3 | 2 | 3 | 0 | 0 | 0 | |
| Ndamukong Suh | DET | 16 | 24 | 10 | 8.0 | 8.0 | 0 | 0 | 2 | 0 | 0 | 0 | |
| 22 | Israel Idonije | CHI | 16 | 29 | 19 | 7.5 | 3.5 | 1 | 0 | 0 | 0 | 0 | 0 |
| 23 | William Hayes | STL | 16 | 29 | 6 | 7.0 | 7.5 | 0 | 1 | 1 | 0 | 0 | 0 |
| Corey Wootton | CHI | 16 | 20 | 7 | 7.0 | 1.0 | 2 | 0 | 1 | 0 | 0 | 0 | |
| 25 | Ahmad Brooks | SF | 16 | 35 | 12 | 6.5 | 5.0 | 2 | 0 | 6 | 1 | 50 | 1 |
| Calais Campbell | ARI | 13 | 50 | 13 | 6.5 | 8.5 | 0 | 0 | 6 | 0 | 0 | 0 | |
| Jason Pierre-Paul | NYG | 16 | 43 | 23 | 6.5 | 8.0 | 1 | 1 | 5 | 1 | 28 | 1 | |
| 28 | Dwan Edwards | CAR | 14 | 27 | 25 | 6.0 | 1.0 | 1 | 0 | 1 | 0 | 0 | 0 |
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