Louisville had already lost one Heisman Trophy candidate for the season in running back Michael Bush. Then, in last week's blowout win over Miami, the Cardinals lost another Heisman hopeful in QB Brian Brohm, who tore a ligament in his right hand and will miss a month. Cantwell will start under center against undefeated Kansas State. Last season he started two games and went 1-1 after Brohm's season-ending knee injury.