2007 Red Sox-Indians
J.D. Drew's debut season in Boston didn't go quite as planned (.270, 11 homers, 64 RBIs), and the much-maligned outfielder was in danger of completely losing yet another fan base. Coming into the game, Drew was 0 for 6 with runners in scoring position in the series. But with two outs and the bases loaded in the first inning, Drew blasted a grand slam into the camera box in straightaway center field. The Red Sox, who had trailed the series 3-1, went on to win Game 6 12-2 and Game 7 11-2.