Before the court cases and eternal infamy, Simpson was a once-in-a-generation college running back. In 1967 he led the country in rushing with 1,451 yards on 266 carries and 11 touchdowns. The following year -- en route to winning the Heisman Trophy -- he ran for 1,709 yards and 22 touchdowns while leading USC to a 9-0-1 regular season record.

Runner-up:
Johnny Lujack, Notre Dame (1943, 46-47)