2000s: Top 10 College Football Upsets

Louisville, then still a member of Conference USA, played host to No. 4 Florida State as the remnants of Tropical Storm Isidore poured down on Cardinal Stadium. The Seminoles built a 13-6 halftime lead, but Dave Ragone and the Cardinals charged back to force overtime. On the first play in OT, Louisville's Anthony Floyd intercepted FSU quarterback Chris Rix near the goal line. With the pressure to answer a score removed, Henry Miller broke off a game-winning 25-yard touchdown run to seal the upset. In 2004, C-USA voted the win the greatest moment in the conference's first decade of existence.