Best Fights of the 2000s

Miguel Cotto's first professional defeat came in a welterweight title defense against Antonio Margarito at the MGM Grand Garden Arena in Las Vegas. After weathering the Puerto Rican's best shots in the early rounds, the Tijuana Tornado used constant pressure to turn the tide. Cotto went down twice in the 11th before his corner threw in the towel. The luster from Margarito's career-defining victory proved short-lived, however, after he was caught attempting to use illegal hand wraps in his very next fight against Shane Mosley.