2005 NLCS: Astros vs. Cardinals, Game 5
Taking a 4-2 lead into the top of the 9th with their first pennant three outs away, the Houston Astros brought in closer Brad Lidge to shut the door on the St. Louis Cardinals. Lidge picked up the first two outs before surrendering a single to David Eckstein and a walk to Jim Edmonds. That allowed Albert Pujols to step to the plate, and he blasted a towering three-run home run to give the Cardinals a 5-4 victory in Game 5 of the 2005 NLCS. The Astros would bounce back to win Game 6, and the series, two days later.