O.J. Simpson: 250 yards, 2 TDs
Buffalo vs. New England - 9/16/73
Some running backs come out of the gate stronger than others, which is why we decided to highlight the greatest rushing performance on opening weekend history. Dating back to 1933, no back has ever turned in a better kickoff-weekend effort than Hall of Famer O.J. Simpson. The Bills former bruiser burned the New England Patriots for 250 yards and two touchdowns on 29 carries in a brilliant Week 1 showing.